Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration
During the COVID-19 pandemic, the treatment of pulmonary fungal infection faced noteworthy challenges. Amphotericin B has shown promising therapeutic effects as an inhalation treatment for pulmonary fungal infections, especially those associated with the COVID-19 virus, due to its rare resistance. H...
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MDPI AG
2023-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/12/4840 |
| _version_ | 1797593255848706048 |
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| author | Juan Wang Jia Wang Xinzhong Wang Zhen Wang |
| author_facet | Juan Wang Jia Wang Xinzhong Wang Zhen Wang |
| author_sort | Juan Wang |
| collection | DOAJ |
| description | During the COVID-19 pandemic, the treatment of pulmonary fungal infection faced noteworthy challenges. Amphotericin B has shown promising therapeutic effects as an inhalation treatment for pulmonary fungal infections, especially those associated with the COVID-19 virus, due to its rare resistance. However, because the drug frequently produces renal toxicity, its effective dose is limited in clinical use. In this work, the DPPC/DPPG mixed monolayer was used as the pulmonary surfactant monolayer to study the interaction between amphotericin B and the pulmonary surfactant monolayer during inhalation therapy using the Langmuir technique and atomic force microscopy. The effects of different molar ratios of AmB on the thermodynamic properties and surface morphology of the pulmonary surfactant monolayer at different surface pressures was evaluated. The results showed that when the molar ratio of AmB to lipids in the pulmonary surfactant was less than 1:1, the main intermolecular force was attractive at a surface pressure greater than 10 mN/m. This drug had little effect on the phase transition point of the DPPC/DPPG monolayer, but decreased the height of the monolayer at 15 mN/m and 25 mN/m. When the molar ratio of AmB to lipids was greater than 1:1, the intermolecular force was mainly repulsive at a surface pressure greater than 15 mN/m, and AmB increased the height of the DPPC/DPPG monolayer at both 15 mN/m and 25 mN/m. These results are helpful in understanding the interaction between the pulmonary surfactant model monolayer and different doses of drugs at various surface tensions during respiration. |
| first_indexed | 2024-03-11T02:06:24Z |
| format | Article |
| id | doaj.art-89f9dcef2ed24087be23743b62121d39 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T02:06:24Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-89f9dcef2ed24087be23743b62121d392023-11-18T11:51:04ZengMDPI AGMolecules1420-30492023-06-012812484010.3390/molecules28124840Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during RespirationJuan Wang0Jia Wang1Xinzhong Wang2Zhen Wang3Shaanxi Engineering Research Center of Controllable Neutron Source, School of Electronic Information, Xijing University, Xi’an 710123, ChinaShaanxi Engineering Research Center of Controllable Neutron Source, School of Electronic Information, Xijing University, Xi’an 710123, ChinaXi’an Key Laboratory of Human-Machine Integration and Control Technology for Intelligent Rehabilitation, School of Computer Science, Xijing University, Xi’an 710123, ChinaXi’an Key Laboratory of Human-Machine Integration and Control Technology for Intelligent Rehabilitation, School of Computer Science, Xijing University, Xi’an 710123, ChinaDuring the COVID-19 pandemic, the treatment of pulmonary fungal infection faced noteworthy challenges. Amphotericin B has shown promising therapeutic effects as an inhalation treatment for pulmonary fungal infections, especially those associated with the COVID-19 virus, due to its rare resistance. However, because the drug frequently produces renal toxicity, its effective dose is limited in clinical use. In this work, the DPPC/DPPG mixed monolayer was used as the pulmonary surfactant monolayer to study the interaction between amphotericin B and the pulmonary surfactant monolayer during inhalation therapy using the Langmuir technique and atomic force microscopy. The effects of different molar ratios of AmB on the thermodynamic properties and surface morphology of the pulmonary surfactant monolayer at different surface pressures was evaluated. The results showed that when the molar ratio of AmB to lipids in the pulmonary surfactant was less than 1:1, the main intermolecular force was attractive at a surface pressure greater than 10 mN/m. This drug had little effect on the phase transition point of the DPPC/DPPG monolayer, but decreased the height of the monolayer at 15 mN/m and 25 mN/m. When the molar ratio of AmB to lipids was greater than 1:1, the intermolecular force was mainly repulsive at a surface pressure greater than 15 mN/m, and AmB increased the height of the DPPC/DPPG monolayer at both 15 mN/m and 25 mN/m. These results are helpful in understanding the interaction between the pulmonary surfactant model monolayer and different doses of drugs at various surface tensions during respiration.https://www.mdpi.com/1420-3049/28/12/4840pulmonary surfactantamphotericin BLangmuir monolayeratomic force microscopy |
| spellingShingle | Juan Wang Jia Wang Xinzhong Wang Zhen Wang Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration Molecules pulmonary surfactant amphotericin B Langmuir monolayer atomic force microscopy |
| title | Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration |
| title_full | Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration |
| title_fullStr | Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration |
| title_full_unstemmed | Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration |
| title_short | Effect of Amphotericin B on the Thermodynamic Properties and Surface Morphology of the Pulmonary Surfactant Model Monolayer during Respiration |
| title_sort | effect of amphotericin b on the thermodynamic properties and surface morphology of the pulmonary surfactant model monolayer during respiration |
| topic | pulmonary surfactant amphotericin B Langmuir monolayer atomic force microscopy |
| url | https://www.mdpi.com/1420-3049/28/12/4840 |
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