The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study
BackgroundIt has been reported that decreased muscle mass combined with excessive visceral adipose tissue are significantly correlated with the risk of non-alcoholic fatty liver disease (NAFLD). However, it has not been explored among populations with metabolic dysfunction-associated fatty liver dis...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1246157/full |
| _version_ | 1797633005966065664 |
|---|---|
| author | Mengchen Xing Yanlan Ni Ye Zhang Xiaoqian Zhao Xin Yu |
| author_facet | Mengchen Xing Yanlan Ni Ye Zhang Xiaoqian Zhao Xin Yu |
| author_sort | Mengchen Xing |
| collection | DOAJ |
| description | BackgroundIt has been reported that decreased muscle mass combined with excessive visceral adipose tissue are significantly correlated with the risk of non-alcoholic fatty liver disease (NAFLD). However, it has not been explored among populations with metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes. We aimed to investigate whether appendicular skeletal muscle mass to visceral fat area ratio (SVR), an indicator of sarcopenic obesity, influences on the risk of MAFLD subtypes and its hepatic condition in middle-aged and elderly population.MethodsA total of 4,003 middle-aged and elderly subjects were finally enrolled in this single-center retrospective study. Abdominal ultrasonography was employed for hepatic steatosis diagnosis. Participants were divided into four groups: diabetes-MAFLD, overweight/obese-MAFLD, lean-MAFLD and no MAFLD. Appendicular skeletal muscle mass as well as visceral fat area (VAF) was estimated by bioimpedance analysis measurements. Liver fibrosis was defined as a Fibrosis-4 index (FIB-4) and the NAFLD Fibrosis Score (NFS). Multivariate logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval between SVR and MAFLD subtypes/hepatic condition stratified by sex.ResultsParticipants with MAFLD subtypes had a significant lower value of SVR compared with those without MAFLD (P<0.001), while high quartiles of FIB-4 and NFS also showed a decreasing value of SVR in comparison with its lower quartiles (Pfor trend<0.001). The lowest quartile of SVR increased the prevalence of MAFLD subtypes [adjusted OR (95%CI): 2.96 (1.48 ~ 5.93) male /3.30(1.46 ~ 7.46) female for diabetes-MAFLD, 1.91(1.26 ~ 2.88) male /4.48(1.91 ~ 10.49) female for overweight/obese-MAFLD and 4.01(1.46 ~ 10.98) male/2.53(1.19 ~ 5.37) female for lean-MAFLD groups] compared with the highest quartile of SVR (all Pfor trend<0.001). Besides, the interaction effect of gender on the relationship between SVR and MAFLD subtypes was statistically significant (all Pfor interaction<0.001).Restricted cubic spline indicated an inverse association between SVR and the risk of MAFLD subtypes with linearity (all P for non-linearity>0.05). The lowest quartile of SVR also increases the risk of MAFLD fibrosis in both males and females.ConclusionOur study concluded that a decrease in SVR (appendicular skeletal muscle mass divided by visceral fat area) is significantly associated with an increased prevalence of developing MAFLD subtypes and liver fibrosis in middle-aged and older persons of both genders. |
| first_indexed | 2024-03-11T11:45:42Z |
| format | Article |
| id | doaj.art-89fb0792b20a4c72b3ec5f756add22f9 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T11:45:42Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-89fb0792b20a4c72b3ec5f756add22f92023-11-09T14:26:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12461571246157The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective studyMengchen Xing0Yanlan Ni1Ye Zhang2Xiaoqian Zhao3Xin Yu4Department of Thyroid, Breast, and Gastrointestinal Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Thyroid, Breast, and Gastrointestinal Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Minimally Invasive Laparoscopy, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaEmergency Intensive Care Unit, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Hepatobiliary Surgery, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaBackgroundIt has been reported that decreased muscle mass combined with excessive visceral adipose tissue are significantly correlated with the risk of non-alcoholic fatty liver disease (NAFLD). However, it has not been explored among populations with metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes. We aimed to investigate whether appendicular skeletal muscle mass to visceral fat area ratio (SVR), an indicator of sarcopenic obesity, influences on the risk of MAFLD subtypes and its hepatic condition in middle-aged and elderly population.MethodsA total of 4,003 middle-aged and elderly subjects were finally enrolled in this single-center retrospective study. Abdominal ultrasonography was employed for hepatic steatosis diagnosis. Participants were divided into four groups: diabetes-MAFLD, overweight/obese-MAFLD, lean-MAFLD and no MAFLD. Appendicular skeletal muscle mass as well as visceral fat area (VAF) was estimated by bioimpedance analysis measurements. Liver fibrosis was defined as a Fibrosis-4 index (FIB-4) and the NAFLD Fibrosis Score (NFS). Multivariate logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval between SVR and MAFLD subtypes/hepatic condition stratified by sex.ResultsParticipants with MAFLD subtypes had a significant lower value of SVR compared with those without MAFLD (P<0.001), while high quartiles of FIB-4 and NFS also showed a decreasing value of SVR in comparison with its lower quartiles (Pfor trend<0.001). The lowest quartile of SVR increased the prevalence of MAFLD subtypes [adjusted OR (95%CI): 2.96 (1.48 ~ 5.93) male /3.30(1.46 ~ 7.46) female for diabetes-MAFLD, 1.91(1.26 ~ 2.88) male /4.48(1.91 ~ 10.49) female for overweight/obese-MAFLD and 4.01(1.46 ~ 10.98) male/2.53(1.19 ~ 5.37) female for lean-MAFLD groups] compared with the highest quartile of SVR (all Pfor trend<0.001). Besides, the interaction effect of gender on the relationship between SVR and MAFLD subtypes was statistically significant (all Pfor interaction<0.001).Restricted cubic spline indicated an inverse association between SVR and the risk of MAFLD subtypes with linearity (all P for non-linearity>0.05). The lowest quartile of SVR also increases the risk of MAFLD fibrosis in both males and females.ConclusionOur study concluded that a decrease in SVR (appendicular skeletal muscle mass divided by visceral fat area) is significantly associated with an increased prevalence of developing MAFLD subtypes and liver fibrosis in middle-aged and older persons of both genders.https://www.frontiersin.org/articles/10.3389/fnut.2023.1246157/fullskeletal muscle mass to visceral fat area ratiometabolic dysfunction-associated fatty liver disease subtypesgenderfibrosismiddle-agedelderly |
| spellingShingle | Mengchen Xing Yanlan Ni Ye Zhang Xiaoqian Zhao Xin Yu The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study Frontiers in Nutrition skeletal muscle mass to visceral fat area ratio metabolic dysfunction-associated fatty liver disease subtypes gender fibrosis middle-aged elderly |
| title | The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study |
| title_full | The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study |
| title_fullStr | The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study |
| title_full_unstemmed | The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study |
| title_short | The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study |
| title_sort | relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction associated fatty liver disease subtypes in middle aged and elderly population a single center retrospective study |
| topic | skeletal muscle mass to visceral fat area ratio metabolic dysfunction-associated fatty liver disease subtypes gender fibrosis middle-aged elderly |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1246157/full |
| work_keys_str_mv | AT mengchenxing therelationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT yanlanni therelationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT yezhang therelationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT xiaoqianzhao therelationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT xinyu therelationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT mengchenxing relationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT yanlanni relationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT yezhang relationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT xiaoqianzhao relationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy AT xinyu relationshipbetweenskeletalmusclemasstovisceralfatarearatioandmetabolicdysfunctionassociatedfattyliverdiseasesubtypesinmiddleagedandelderlypopulationasinglecenterretrospectivestudy |