Cycvalone in the synthesis of nitrogen-, oxygen-containing heterocycles
Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic. Numerous methods of producing cycvalone are known, including industrial ones, but it...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Saratov State University
2023-06-01
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| Series: | Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология |
| Subjects: | |
| Online Access: | https://ichbe.sgu.ru/sites/ichbe.sgu.ru/files/text-pdf/2023/06/himiya_2023_2-159-165.pdf |
| Summary: | Cycvalone is an analogue of curcumin (EE conformation), exhibits a wide range of biological activity (antioxidant, hepatoprotective, membrane stabilizing, anti-ulcer) and is used in medical practice as a choleretic. Numerous methods of producing cycvalone are known, including industrial ones, but its reactions have been studied much less. Some reactions of cycvalone with N, C-nucleophiles (hydrazines, malononitrile) have been carried out. Reactions with getarylamines that could lead to the synthesis of compounds including pharmacophore fragments remained completely unexplored. We have used cycvalone as a substrate for the synthesis of nitrogen-, oxygen-containing heterosystems of a number of chromenopyrimidine, aminochromencarbonitrile, indazole, triazoloquinazoline. The structure of the obtained new substances has been established by spectral methods (IR, NMR). Schemes of formation of reaction products have been proposed. |
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| ISSN: | 1816-9775 2541-8971 |