Glial Cell Dysfunction in <i>C9orf72</i>-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Glial Cell Dysfunction in <i>C9orf72</i>-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Since the discovery of the chromosome 9 open reading frame 72 (<i>C9orf72</i>) repeat expansion mutation in 2011 as the most common genetic abnormality in amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease) and frontotemporal dementia (FTD), progress in understanding...

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Bibliographic Details
Main Authors: Mehdi Ghasemi, Kiandokht Keyhanian, Catherine Douthwright
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
<i>C9orf72</i> gene
<i>C9orf72</i> repeat expansion mutation
amyotrophic lateral sclerosis (ALS)
frontotemporal dementia (FTD)
astrocytes
microglia
Online Access:https://www.mdpi.com/2073-4409/10/2/249

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