Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process
The aim of the work was to estimate a wound-healing effect of soft drug products from the Pentaphylloides fruticosa L. shoots on the model of planar skin-fascial wound. The liniment was developed with the use of the NanoDeBee 30 device and the ointment was developed with the use of pharmaceutical te...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2016-09-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/294 |
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| author | V. E. Khitrikheev B. N. Garmaev M. I. Balkhaev L. V. Khibkhenov S. P. Khankhasykov I. G. Nikolaeva |
| author_facet | V. E. Khitrikheev B. N. Garmaev M. I. Balkhaev L. V. Khibkhenov S. P. Khankhasykov I. G. Nikolaeva |
| author_sort | V. E. Khitrikheev |
| collection | DOAJ |
| description | The aim of the work was to estimate a wound-healing effect of soft drug products from the Pentaphylloides fruticosa L. shoots on the model of planar skin-fascial wound. The liniment was developed with the use of the NanoDeBee 30 device and the ointment was developed with the use of pharmaceutical technology. Experiments were carried out on white male Wistar rats. The skin injury was simulated by inflicting planar wounds 2.0 x 2.0 cm in size. The 5%-liniment and 5% ointment from P. fruticosa were put on the wounds of the first and second experimental groups respectively. In the third group the wounds were treated with glycerin-vaseline ointment. Bioptate of the wound surface was taken on the 7th, 14th and 21st day. Histological preparations were studied using standard methods. Cell elements of the first group animals were displayed as fibroblasts and fibrocytes; it was noted high level of collagen organization that testified the effective staging of the wound process in this case. The amount of fibrocytes and fibroblasts and ratio between juvenile and mature forms of collagen-producing cells vary in the first and second groups. Biopsy material obtained from the animals of the third group only on the 21st day corresponded to the picture observed in animals of the 1st group on the 14th day. The findings of the study verify that the use of the product obtained on NanoDeBee device provides the earlier forming of the scar as compared with the ointment developed using pharmaceutical technology. |
| first_indexed | 2024-03-08T12:19:02Z |
| format | Article |
| id | doaj.art-8a00da0fc6ea4410bd1c22838da445eb |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:19:25Z |
| publishDate | 2016-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-8a00da0fc6ea4410bd1c22838da445eb2024-03-28T07:49:16ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962016-09-011512913210.12737/23408294Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound processV. E. Khitrikheev0B. N. Garmaev1M. I. Balkhaev2L. V. Khibkhenov3S. P. Khankhasykov4I. G. Nikolaeva5Buryat State UniversityInstitute of General and Experimental Biology SB RASBuryat State UniversityBuryat State Agricultural Academy named after V.R. PhilippovBuryat State Agricultural Academy named after V.R. PhilippovInstitute of General and Experimental Biology SB RASThe aim of the work was to estimate a wound-healing effect of soft drug products from the Pentaphylloides fruticosa L. shoots on the model of planar skin-fascial wound. The liniment was developed with the use of the NanoDeBee 30 device and the ointment was developed with the use of pharmaceutical technology. Experiments were carried out on white male Wistar rats. The skin injury was simulated by inflicting planar wounds 2.0 x 2.0 cm in size. The 5%-liniment and 5% ointment from P. fruticosa were put on the wounds of the first and second experimental groups respectively. In the third group the wounds were treated with glycerin-vaseline ointment. Bioptate of the wound surface was taken on the 7th, 14th and 21st day. Histological preparations were studied using standard methods. Cell elements of the first group animals were displayed as fibroblasts and fibrocytes; it was noted high level of collagen organization that testified the effective staging of the wound process in this case. The amount of fibrocytes and fibroblasts and ratio between juvenile and mature forms of collagen-producing cells vary in the first and second groups. Biopsy material obtained from the animals of the third group only on the 21st day corresponded to the picture observed in animals of the 1st group on the 14th day. The findings of the study verify that the use of the product obtained on NanoDeBee device provides the earlier forming of the scar as compared with the ointment developed using pharmaceutical technology.https://www.actabiomedica.ru/jour/article/view/294pentaphylloides fruticosa l. sproutslinimentointmentwound process |
| spellingShingle | V. E. Khitrikheev B. N. Garmaev M. I. Balkhaev L. V. Khibkhenov S. P. Khankhasykov I. G. Nikolaeva Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process Acta Biomedica Scientifica pentaphylloides fruticosa l. sprouts liniment ointment wound process |
| title | Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process |
| title_full | Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process |
| title_fullStr | Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process |
| title_full_unstemmed | Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process |
| title_short | Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process |
| title_sort | influence of soft finished pharmaproducts based on pentaphylloides fruticosa l on the course of wound process |
| topic | pentaphylloides fruticosa l. sprouts liniment ointment wound process |
| url | https://www.actabiomedica.ru/jour/article/view/294 |
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