An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer

An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer

Abstract Background Tumor cells tend to utilize glycolysis rather than aerobic respiration even under aerobic conditions. OVOL2, an inhibitory C2H2 zinc finger transcription factor, is a potential tumor suppressor in cancers. However, the association between OVOL2 and tumor energy metabolism is unkn...

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Bibliographic Details
Main Authors: Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi, Xiao-Lei Zhu, Ning Li, Hong-Ming Liu, Jun-Feng Lin, Jian-Weng Wang, Guang Zhao, Guan-Zhi Ye, Bo-An Li, Qi-Cong Luo, Jie Jiang
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Cell Communication and Signaling
Subjects:
NSCLC
OVOL2
NF-κB signaling
Glucose import
Online Access:https://doi.org/10.1186/s12964-022-00845-z

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