Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties

Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties

Abstract Background Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by 5′-adenosine monophosphate-activated protein kinase (AMPK), a master energy sensor of the cell. Clinically, treatment with Z...

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Bibliographic Details
Main Authors: Amber F. MacDonald, Ahmed Bettaieb, Dallas R. Donohoe, Dina S. Alani, Anna Han, Yi Zhao, Jay Whelan
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Zyflamend
AMPK
LKB1
CaMKK2
CWR22Rv1
HeLa
Online Access:http://link.springer.com/article/10.1186/s12906-018-2255-0

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