Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly
Proteins and peptides, built from precisely defined amino acid sequences, are an important class of biomolecules that play a vital role in most biological functions. Preparation of nanostructures through functionalization of natural, hydrophilic proteins/peptides with synthetic polymers or upon self...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/13/16/2603 |
| _version_ | 1797522302364024832 |
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| author | Spyridon Varlas Georgia L. Maitland Matthew J. Derry |
| author_facet | Spyridon Varlas Georgia L. Maitland Matthew J. Derry |
| author_sort | Spyridon Varlas |
| collection | DOAJ |
| description | Proteins and peptides, built from precisely defined amino acid sequences, are an important class of biomolecules that play a vital role in most biological functions. Preparation of nanostructures through functionalization of natural, hydrophilic proteins/peptides with synthetic polymers or upon self-assembly of all-synthetic amphiphilic copolypept(o)ides and amino acid-containing polymers enables access to novel protein-mimicking biomaterials with superior physicochemical properties and immense biorelevant scope. In recent years, polymerization-induced self-assembly (PISA) has been established as an efficient and versatile alternative method to existing self-assembly procedures for the reproducible development of block copolymer nano-objects in situ at high concentrations and, thus, provides an ideal platform for engineering protein-inspired nanomaterials. In this review article, the different strategies employed for direct construction of protein-, (poly)peptide-, and amino acid-based nanostructures via PISA are described with particular focus on the characteristics of the developed block copolymer assemblies, as well as their utilization in various pharmaceutical and biomedical applications. |
| first_indexed | 2024-03-10T08:27:28Z |
| format | Article |
| id | doaj.art-8a02fd3d67c142aa9b70f62ca8352aa6 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T08:27:28Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-8a02fd3d67c142aa9b70f62ca8352aa62023-11-22T09:21:33ZengMDPI AGPolymers2073-43602021-08-011316260310.3390/polym13162603Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-AssemblySpyridon Varlas0Georgia L. Maitland1Matthew J. Derry2Department of Chemistry, University College London, London WC1H 0AJ, UKAston Institute of Materials Research, Aston University, Birmingham B4 7ET, UKAston Institute of Materials Research, Aston University, Birmingham B4 7ET, UKProteins and peptides, built from precisely defined amino acid sequences, are an important class of biomolecules that play a vital role in most biological functions. Preparation of nanostructures through functionalization of natural, hydrophilic proteins/peptides with synthetic polymers or upon self-assembly of all-synthetic amphiphilic copolypept(o)ides and amino acid-containing polymers enables access to novel protein-mimicking biomaterials with superior physicochemical properties and immense biorelevant scope. In recent years, polymerization-induced self-assembly (PISA) has been established as an efficient and versatile alternative method to existing self-assembly procedures for the reproducible development of block copolymer nano-objects in situ at high concentrations and, thus, provides an ideal platform for engineering protein-inspired nanomaterials. In this review article, the different strategies employed for direct construction of protein-, (poly)peptide-, and amino acid-based nanostructures via PISA are described with particular focus on the characteristics of the developed block copolymer assemblies, as well as their utilization in various pharmaceutical and biomedical applications.https://www.mdpi.com/2073-4360/13/16/2603proteinspolypeptidesα-amino acidsblock copolymerspolymerization-induced self-assemblyprotein–polymer conjugates |
| spellingShingle | Spyridon Varlas Georgia L. Maitland Matthew J. Derry Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly Polymers proteins polypeptides α-amino acids block copolymers polymerization-induced self-assembly protein–polymer conjugates |
| title | Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly |
| title_full | Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly |
| title_fullStr | Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly |
| title_full_unstemmed | Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly |
| title_short | Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly |
| title_sort | protein poly peptide and amino acid based nanostructures prepared via polymerization induced self assembly |
| topic | proteins polypeptides α-amino acids block copolymers polymerization-induced self-assembly protein–polymer conjugates |
| url | https://www.mdpi.com/2073-4360/13/16/2603 |
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