Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution
Abstract Background High tumor recurrence and dismal survival rates after curative intended resection for hepatocellular carcinoma (HCC) are still concerning. The primary goal was to assess predictive factors associated with disease-free (DFS) and overall survival (OS) in a subset of patients with H...
| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
BMC
2024-04-01
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| coleção: | BMC Surgery |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s12893-024-02399-y |
| _version_ | 1827284521424257024 |
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| author | Sascha Vaghiri Dimitrios Prassas Onur Mustafov Sinan Kalmuk Wolfram Trudo Knoefel Nadja Lehwald-Tywuschik Andrea Alexander Levent Dizdar |
| author_facet | Sascha Vaghiri Dimitrios Prassas Onur Mustafov Sinan Kalmuk Wolfram Trudo Knoefel Nadja Lehwald-Tywuschik Andrea Alexander Levent Dizdar |
| author_sort | Sascha Vaghiri |
| collection | DOAJ |
| description | Abstract Background High tumor recurrence and dismal survival rates after curative intended resection for hepatocellular carcinoma (HCC) are still concerning. The primary goal was to assess predictive factors associated with disease-free (DFS) and overall survival (OS) in a subset of patients with HCC undergoing hepatic resection (HR). Methods Between 08/2004–7/2021, HR for HCC was performed in 188 patients at our institution. Data allocation was conducted from a prospectively maintained database. The prognostic impact of clinico-pathological factors on DFS and OS was assessed by using uni- and multivariate Cox regression analyses. Survival curves were generated with the Kaplan Meier method. Results The postoperative 1-, 3- and 5- year overall DFS and OS rates were 77.9%, 49.7%, 41% and 72.7%, 54.7%, 38.8%, respectively. Tumor diameter ≥ 45 mm [HR 1.725; (95% CI 1.091–2.727); p = 0.020], intra-abdominal abscess [HR 3.812; (95% CI 1.859–7.815); p < 0.0001], and preoperative chronic alcohol abuse [HR 1.831; (95% CI 1.102–3.042); p = 0.020] were independently predictive for DFS while diabetes mellitus [HR 1.714; (95% CI 1.147–2.561); p = 0.009), M-Stage [HR 2.656; (95% CI 1.034–6.826); p = 0.042], V-Stage [HR 1.946; (95% CI 1.299–2.915); p = 0.001, Sepsis [HR 10.999; (95% CI 5.167–23.412); p < 0.0001], and ISGLS B/C [HR 2.008; (95% CI 1.273–3.168); p = 0.003] were significant determinants of OS. Conclusions Despite high postoperative recurrence rates, an acceptable long-term survival in patients after curative HR could be achieved. The Identification of parameters related to OS and DFS improves patient-centered treatment and surveillance strategies. |
| first_indexed | 2024-04-24T09:56:49Z |
| format | Article |
| id | doaj.art-8a0365a13e0a4996973c96ee0db48e7f |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-04-24T09:56:49Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-8a0365a13e0a4996973c96ee0db48e7f2024-04-14T11:06:42ZengBMCBMC Surgery1471-24822024-04-0124111310.1186/s12893-024-02399-yWhich factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institutionSascha Vaghiri0Dimitrios Prassas1Onur Mustafov2Sinan Kalmuk3Wolfram Trudo Knoefel4Nadja Lehwald-Tywuschik5Andrea Alexander6Levent Dizdar7Department of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfDepartment of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfDepartment of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfDepartment of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfDepartment of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfDepartment of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfDepartment of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfDepartment of Surgery (A), Heinrich-Heine-University and University Hospital DuesseldorfAbstract Background High tumor recurrence and dismal survival rates after curative intended resection for hepatocellular carcinoma (HCC) are still concerning. The primary goal was to assess predictive factors associated with disease-free (DFS) and overall survival (OS) in a subset of patients with HCC undergoing hepatic resection (HR). Methods Between 08/2004–7/2021, HR for HCC was performed in 188 patients at our institution. Data allocation was conducted from a prospectively maintained database. The prognostic impact of clinico-pathological factors on DFS and OS was assessed by using uni- and multivariate Cox regression analyses. Survival curves were generated with the Kaplan Meier method. Results The postoperative 1-, 3- and 5- year overall DFS and OS rates were 77.9%, 49.7%, 41% and 72.7%, 54.7%, 38.8%, respectively. Tumor diameter ≥ 45 mm [HR 1.725; (95% CI 1.091–2.727); p = 0.020], intra-abdominal abscess [HR 3.812; (95% CI 1.859–7.815); p < 0.0001], and preoperative chronic alcohol abuse [HR 1.831; (95% CI 1.102–3.042); p = 0.020] were independently predictive for DFS while diabetes mellitus [HR 1.714; (95% CI 1.147–2.561); p = 0.009), M-Stage [HR 2.656; (95% CI 1.034–6.826); p = 0.042], V-Stage [HR 1.946; (95% CI 1.299–2.915); p = 0.001, Sepsis [HR 10.999; (95% CI 5.167–23.412); p < 0.0001], and ISGLS B/C [HR 2.008; (95% CI 1.273–3.168); p = 0.003] were significant determinants of OS. Conclusions Despite high postoperative recurrence rates, an acceptable long-term survival in patients after curative HR could be achieved. The Identification of parameters related to OS and DFS improves patient-centered treatment and surveillance strategies.https://doi.org/10.1186/s12893-024-02399-yOverall and disease free survivalHepatocellular carcinomaPredictive factorsCurative resection |
| spellingShingle | Sascha Vaghiri Dimitrios Prassas Onur Mustafov Sinan Kalmuk Wolfram Trudo Knoefel Nadja Lehwald-Tywuschik Andrea Alexander Levent Dizdar Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution BMC Surgery Overall and disease free survival Hepatocellular carcinoma Predictive factors Curative resection |
| title | Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution |
| title_full | Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution |
| title_fullStr | Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution |
| title_full_unstemmed | Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution |
| title_short | Which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma? Results from a European institution |
| title_sort | which factors predict tumor recurrence and survival after curative hepatectomy in hepatocellular carcinoma results from a european institution |
| topic | Overall and disease free survival Hepatocellular carcinoma Predictive factors Curative resection |
| url | https://doi.org/10.1186/s12893-024-02399-y |
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