Peroxiredoxin 6 mediates acetaminophen-induced hepatocyte death through JNK activation
Acetaminophen (APAP) is one of the most frequently used drugs; however, its overdose leads to acute liver injury. Recently, studies have reported that the adduction of peroxiredoxin 6 (PRDX6), a member of the PRDX family of antioxidant enzymes, is associated with liver diseases. However, the role of...
Main Authors: | Dong Hun Lee, Young Suk Jung, Jaesuk Yun, Sang Bae Han, Yoon Seok Roh, Min Jong Song, Jin Tae Hong |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-05-01
|
Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231719314855 |
Similar Items
-
Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK
by: Eun Su Jeon, et al.
Published: (2006-03-01) -
Peroxiredoxin 1 alleviates oxygen-glucose deprivation/ reoxygenation injury in N2a cells via suppressing the JNK/caspase-3 pathway
by: Yang Yuan, et al.
Published: (2023-11-01) -
JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression
by: Chenxi Shi, et al.
Published: (2019-09-01) -
Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6
by: Isaac Mohar, et al.
Published: (2014-01-01) -
Lysophosphatidylcholine stimulates phospholipase D activity in mouse peritoneal macrophages
by: Antonio Gómez-Muñoz, et al.
Published: (1999-06-01)