Effects of Imatinib Mesylate in Mouse Models of Multiple Sclerosis and In vitro Determinants

Effects of Imatinib Mesylate in Mouse Models of Multiple Sclerosis and In vitro Determinants

Experimental  autoimmune  encephalomyelitis (EAE)  is  a  mouse  model  for  multiple sclerosis (MS), This autoimmune disease is mainly mediated by adaptive and innate immune responses that lead to an inflammatory demyelination and axonal damage. Imatinib mesylate is a  selective protein  tyrosine k...

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Main Authors: Gholamreza Azizi, Mohsen Reza Haidari, Mohammadreza Khorramizadeh, Fatemeh Naddafi, Reza Sadria, Mohammad Hassan Javanbakht, Reza Sedaghat, Farzaneh Tofighi Zavareh, Abbas Mirshafiey
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2014-06-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
Experimental autoimmune encephalomyelitis
Imatinib mesylate
Matrix metalloproteinase-2
Multiple Sclerosis
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/456

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