Recent highlights in biosynthesis research using stable isotopes
The long and successful history of isotopic labeling experiments within natural products research has both changed and deepened our understanding of biosynthesis. As demonstrated in this article, the usage of isotopes is not at all old-fashioned, but continues to give important insights into biosynt...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2015-12-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.11.271 |
| _version_ | 1819275173670420480 |
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| author | Jan Rinkel Jeroen S. Dickschat |
| author_facet | Jan Rinkel Jeroen S. Dickschat |
| author_sort | Jan Rinkel |
| collection | DOAJ |
| description | The long and successful history of isotopic labeling experiments within natural products research has both changed and deepened our understanding of biosynthesis. As demonstrated in this article, the usage of isotopes is not at all old-fashioned, but continues to give important insights into biosynthetic pathways of secondary metabolites. This review with 85 cited references is structured by separate discussions of compounds from different classes including polyketides, non-ribosomal peptides, their hybrids, terpenoids, and aromatic compounds formed via the shikimate pathway. The text does not aim at a comprehensive overview, but instead a selection of recent important examples of isotope usage within biosynthetic studies is presented, with a special emphasis on mechanistic surprises. |
| first_indexed | 2024-12-23T23:20:07Z |
| format | Article |
| id | doaj.art-8a05f1136d67476281878775db04b761 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-23T23:20:07Z |
| publishDate | 2015-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-8a05f1136d67476281878775db04b7612022-12-21T17:26:22ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-12-011112493250810.3762/bjoc.11.2711860-5397-11-271Recent highlights in biosynthesis research using stable isotopesJan Rinkel0Jeroen S. Dickschat1Kekulé-Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Str. 1, 53121 Bonn, GermanyKekulé-Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Str. 1, 53121 Bonn, GermanyThe long and successful history of isotopic labeling experiments within natural products research has both changed and deepened our understanding of biosynthesis. As demonstrated in this article, the usage of isotopes is not at all old-fashioned, but continues to give important insights into biosynthetic pathways of secondary metabolites. This review with 85 cited references is structured by separate discussions of compounds from different classes including polyketides, non-ribosomal peptides, their hybrids, terpenoids, and aromatic compounds formed via the shikimate pathway. The text does not aim at a comprehensive overview, but instead a selection of recent important examples of isotope usage within biosynthetic studies is presented, with a special emphasis on mechanistic surprises.https://doi.org/10.3762/bjoc.11.271biosynthesisenzyme mechanismsisotopeslabeling experimentsnatural products |
| spellingShingle | Jan Rinkel Jeroen S. Dickschat Recent highlights in biosynthesis research using stable isotopes Beilstein Journal of Organic Chemistry biosynthesis enzyme mechanisms isotopes labeling experiments natural products |
| title | Recent highlights in biosynthesis research using stable isotopes |
| title_full | Recent highlights in biosynthesis research using stable isotopes |
| title_fullStr | Recent highlights in biosynthesis research using stable isotopes |
| title_full_unstemmed | Recent highlights in biosynthesis research using stable isotopes |
| title_short | Recent highlights in biosynthesis research using stable isotopes |
| title_sort | recent highlights in biosynthesis research using stable isotopes |
| topic | biosynthesis enzyme mechanisms isotopes labeling experiments natural products |
| url | https://doi.org/10.3762/bjoc.11.271 |
| work_keys_str_mv | AT janrinkel recenthighlightsinbiosynthesisresearchusingstableisotopes AT jeroensdickschat recenthighlightsinbiosynthesisresearchusingstableisotopes |