Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicks
Escherichia coli (E.coli) infections pose significant health risks to poultry and humans globally. In the face of antibiotic-resistant strains, metal oxide nanoparticles and plant extracts have emerged as promising alternatives. This study evaluated the effectiveness of copper oxide nanoparticles (...
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| Format: | Article |
| Language: | English |
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Assiut University
2024-03-01
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| Series: | Journal of Advanced Veterinary Research |
| Subjects: | |
| Online Access: | https://www.advetresearch.com/index.php/AVR/article/view/1692 |
| _version_ | 1797267260847423488 |
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| author | Sawsan S. Elbasuni Mohamed A. Abaza Marwa A. Abdelmagid Osama Ahmed Ahmed Maher Mai O. Nada Marwa I. Abdel Haleem |
| author_facet | Sawsan S. Elbasuni Mohamed A. Abaza Marwa A. Abdelmagid Osama Ahmed Ahmed Maher Mai O. Nada Marwa I. Abdel Haleem |
| author_sort | Sawsan S. Elbasuni |
| collection | DOAJ |
| description |
Escherichia coli (E.coli) infections pose significant health risks to poultry and humans globally. In the face of antibiotic-resistant strains, metal oxide nanoparticles and plant extracts have emerged as promising alternatives. This study evaluated the effectiveness of copper oxide nanoparticles (CuO-NPs) and black elderberry extract (BEE) against E. coli O78 infection in specific pathogen-free chicks. The birds were divided into four groups: a negative control NC, a positive control (PC; challenged with E. coli O78), CuO-NPs treatment post-challenge, and BEE treatment post-challenge. Various parameters, including clinical signs, organ lesions, bacterial load, biochemical markers, and histopathology, were assessed. Both CuO-NPs and BEE demonstrated a reduction in clinical morbidity, organ damage, and E. coli counts compared to the PC. However, BEE exhibited slightly greater efficacy in alleviating liver and kidney dysfunction. Overall, CuO-NPs and BEE hold therapeutic potential against avian colibacillosis, likely acting through antimicrobial and immunomodulatory mechanisms. These findings underscore the potential of bio-based nanoparticles and plant extracts as safer, multi-modal alternatives to antibiotics for avian colibacillosis. Further optimization and mechanistic studies are needed to support their clinical application.
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| first_indexed | 2024-03-07T14:02:12Z |
| format | Article |
| id | doaj.art-8a067b48dec24cb4a7a5bceb831bec9b |
| institution | Directory Open Access Journal |
| issn | 2090-6269 2090-6277 |
| language | English |
| last_indexed | 2024-04-25T01:13:46Z |
| publishDate | 2024-03-01 |
| publisher | Assiut University |
| record_format | Article |
| series | Journal of Advanced Veterinary Research |
| spelling | doaj.art-8a067b48dec24cb4a7a5bceb831bec9b2024-03-10T05:05:00ZengAssiut UniversityJournal of Advanced Veterinary Research2090-62692090-62772024-03-01143Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicksSawsan S. Elbasuni0Mohamed A. Abaza1Marwa A. Abdelmagid2Osama Ahmed3Ahmed Maher4Mai O. Nada5Marwa I. Abdel Haleem6Department of Avian and Rabbit Diseases, Faculty of Veterinary Medicine, Benha University, Benha 13736, Egypt. Department of Avian and Rabbit Diseases, Faculty of Veterinary Medicine, Benha University, Benha 13736, Egypt. Reference Laboratory for Veterinary Quality control on poultry production, Animal Health Research Institute, Agriculture Research Center, Giza, Egypt. Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Benha University, Benha 13736, Egypt.Department of Zoonotic diseases, Veterinary Research Institute, National Research Centre, Giza, Egypt.Department of Veterinary Pharmacology, Animal Health Research Institute (AHRI)-Benha Branch, Agriculture Research Center (ARC), Benha 13518, Egypt.Department of Avian and Rabbit Diseases, Faculty of Veterinary Medicine, Benha University, Benha 13736, Egypt. Escherichia coli (E.coli) infections pose significant health risks to poultry and humans globally. In the face of antibiotic-resistant strains, metal oxide nanoparticles and plant extracts have emerged as promising alternatives. This study evaluated the effectiveness of copper oxide nanoparticles (CuO-NPs) and black elderberry extract (BEE) against E. coli O78 infection in specific pathogen-free chicks. The birds were divided into four groups: a negative control NC, a positive control (PC; challenged with E. coli O78), CuO-NPs treatment post-challenge, and BEE treatment post-challenge. Various parameters, including clinical signs, organ lesions, bacterial load, biochemical markers, and histopathology, were assessed. Both CuO-NPs and BEE demonstrated a reduction in clinical morbidity, organ damage, and E. coli counts compared to the PC. However, BEE exhibited slightly greater efficacy in alleviating liver and kidney dysfunction. Overall, CuO-NPs and BEE hold therapeutic potential against avian colibacillosis, likely acting through antimicrobial and immunomodulatory mechanisms. These findings underscore the potential of bio-based nanoparticles and plant extracts as safer, multi-modal alternatives to antibiotics for avian colibacillosis. Further optimization and mechanistic studies are needed to support their clinical application. https://www.advetresearch.com/index.php/AVR/article/view/1692Colibacillosis CuO-NPs Black elderberry extract Chick Microbial count Histopathology |
| spellingShingle | Sawsan S. Elbasuni Mohamed A. Abaza Marwa A. Abdelmagid Osama Ahmed Ahmed Maher Mai O. Nada Marwa I. Abdel Haleem Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicks Journal of Advanced Veterinary Research Colibacillosis CuO-NPs Black elderberry extract Chick Microbial count Histopathology |
| title | Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicks |
| title_full | Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicks |
| title_fullStr | Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicks |
| title_full_unstemmed | Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicks |
| title_short | Clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic Escherichia coli infection in SPF chicks |
| title_sort | clinical assessment of copper oxide nanoparticles and black elderberry extract in therapy of avian pathogenic escherichia coli infection in spf chicks |
| topic | Colibacillosis CuO-NPs Black elderberry extract Chick Microbial count Histopathology |
| url | https://www.advetresearch.com/index.php/AVR/article/view/1692 |
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