Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome
Patients living with comorbid metabolic syndrome (MS) and metabolic disorders such as obesity and type 2 diabetes mellitus carry increased levels of circulating cytokines and systemic low-grade inflammation. Upon viral infection, such patients with all pre-existing backgrounds, specifically dysregul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sungkyunkwan University School of Medi
2020-09-01
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| Series: | Precision and Future Medicine |
| Subjects: | |
| Online Access: | http://www.pfmjournal.org/upload/pdf/pfm-2020-00121.pdf |
| _version_ | 1818097349999722496 |
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| author | Altansuvd Enkhtur Joon-Sup Yoon Chang-Woo Lee |
| author_facet | Altansuvd Enkhtur Joon-Sup Yoon Chang-Woo Lee |
| author_sort | Altansuvd Enkhtur |
| collection | DOAJ |
| description | Patients living with comorbid metabolic syndrome (MS) and metabolic disorders such as obesity and type 2 diabetes mellitus carry increased levels of circulating cytokines and systemic low-grade inflammation. Upon viral infection, such patients with all pre-existing backgrounds, specifically dysregulated inflammatory signalling, leads to rapid viral replication and results in worse clinical outcomes. The increased pro-inflammatory cytokine release is a risk factor, and therefore, targeting inflammatory signalling pathways represents a potential therapeutic target to control the cytokine release, and thereby prevent serious outcomes, such as increased mortality and morbidity. In this review, we elucidate the factors underlying the increased morbidity and mortality in patients with MS and virus infection, particularly coronavirus. |
| first_indexed | 2024-12-10T23:19:07Z |
| format | Article |
| id | doaj.art-8a06f368bf4745d0a8540cc56a3d8cad |
| institution | Directory Open Access Journal |
| issn | 2508-7940 2508-7959 |
| language | English |
| last_indexed | 2024-12-10T23:19:07Z |
| publishDate | 2020-09-01 |
| publisher | Sungkyunkwan University School of Medi |
| record_format | Article |
| series | Precision and Future Medicine |
| spelling | doaj.art-8a06f368bf4745d0a8540cc56a3d8cad2022-12-22T01:29:46ZengSungkyunkwan University School of MediPrecision and Future Medicine2508-79402508-79592020-09-0143839010.23838/pfm.2020.0012184Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndromeAltansuvd Enkhtur0Joon-Sup Yoon1Chang-Woo Lee2 Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, KoreaPatients living with comorbid metabolic syndrome (MS) and metabolic disorders such as obesity and type 2 diabetes mellitus carry increased levels of circulating cytokines and systemic low-grade inflammation. Upon viral infection, such patients with all pre-existing backgrounds, specifically dysregulated inflammatory signalling, leads to rapid viral replication and results in worse clinical outcomes. The increased pro-inflammatory cytokine release is a risk factor, and therefore, targeting inflammatory signalling pathways represents a potential therapeutic target to control the cytokine release, and thereby prevent serious outcomes, such as increased mortality and morbidity. In this review, we elucidate the factors underlying the increased morbidity and mortality in patients with MS and virus infection, particularly coronavirus.http://www.pfmjournal.org/upload/pdf/pfm-2020-00121.pdfcovid-19inflammationjak kinasesmetabolic syndromestat transcription factors |
| spellingShingle | Altansuvd Enkhtur Joon-Sup Yoon Chang-Woo Lee Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome Precision and Future Medicine covid-19 inflammation jak kinases metabolic syndrome stat transcription factors |
| title | Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome |
| title_full | Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome |
| title_fullStr | Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome |
| title_full_unstemmed | Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome |
| title_short | Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome |
| title_sort | factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome |
| topic | covid-19 inflammation jak kinases metabolic syndrome stat transcription factors |
| url | http://www.pfmjournal.org/upload/pdf/pfm-2020-00121.pdf |
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