Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood
Background Childhood weight trajectories may influence cardiometabolic traits and thereby the risk of venous thromboembolism (VTE) later in life. We examined whether overweight and changes in weight status during childhood were associated with risk of VTE in adulthood. Methods and Results We used Da...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.011407 |
| _version_ | 1828876239643869184 |
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| author | Jens Sundbøll Lars Ängquist Kasper Adelborg Line Klingen Gjærde Anne Ording Thorkild I. A. Sørensen Jennifer L. Baker Henrik Toft Sørensen |
| author_facet | Jens Sundbøll Lars Ängquist Kasper Adelborg Line Klingen Gjærde Anne Ording Thorkild I. A. Sørensen Jennifer L. Baker Henrik Toft Sørensen |
| author_sort | Jens Sundbøll |
| collection | DOAJ |
| description | Background Childhood weight trajectories may influence cardiometabolic traits and thereby the risk of venous thromboembolism (VTE) later in life. We examined whether overweight and changes in weight status during childhood were associated with risk of VTE in adulthood. Methods and Results We used Danish medical registries to conduct a population‐based cohort study of Danish schoolchildren aged 7 to 13 years and born during 1930‐1989. We calculated body‐mass index (BMI) z‐scores based on weight and height measurements. We estimated hazard ratios using Cox regressions to examine associations between changes in BMI z‐scores from 7 to 13 years of age and the subsequent risk of VTE. Among 313 998 children, 5007 girls and 5397 boys were diagnosed with VTE as adults. Compared with children with a normal BMI (25th to 75th percentile category) at both ages, children with a BMI persistently above the 75th percentile had a 1.30‐ to 1.50‐fold increased risk of VTE in adulthood. Children who experienced a BMI increase from the 25th to 75th or >75th to 90th percentile to a higher percentile category had a 1.35‐ to 1.70‐fold increased risk of adulthood VTE. Children whose BMI percentile category decreased between 7 and 13 years of age had a VTE risk similar to that of children with a persistently normal BMI. Conclusions Risk of VTE in adulthood was higher in children with a persistently above‐average BMI. Whereas weight gain from 7 to 13 years of age additionally increased VTE risk, remission from overweight by 13 years of age completely reverted the risk. |
| first_indexed | 2024-12-13T08:16:22Z |
| format | Article |
| id | doaj.art-8a0747a90b3a4f99acad97acfd47c43f |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T08:16:22Z |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-8a0747a90b3a4f99acad97acfd47c43f2022-12-21T23:54:06ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-03-018610.1161/JAHA.118.011407Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in AdulthoodJens Sundbøll0Lars Ängquist1Kasper Adelborg2Line Klingen Gjærde3Anne Ording4Thorkild I. A. Sørensen5Jennifer L. Baker6Henrik Toft Sørensen7Department of Clinical Epidemiology Aarhus University Hospital Aarhus DenmarkCenter for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Frederiksberg DenmarkDepartment of Clinical Epidemiology Aarhus University Hospital Aarhus DenmarkCenter for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Frederiksberg DenmarkDepartment of Clinical Epidemiology Aarhus University Hospital Aarhus DenmarkDepartment of Clinical Epidemiology Aarhus University Hospital Aarhus DenmarkCenter for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Frederiksberg DenmarkDepartment of Clinical Epidemiology Aarhus University Hospital Aarhus DenmarkBackground Childhood weight trajectories may influence cardiometabolic traits and thereby the risk of venous thromboembolism (VTE) later in life. We examined whether overweight and changes in weight status during childhood were associated with risk of VTE in adulthood. Methods and Results We used Danish medical registries to conduct a population‐based cohort study of Danish schoolchildren aged 7 to 13 years and born during 1930‐1989. We calculated body‐mass index (BMI) z‐scores based on weight and height measurements. We estimated hazard ratios using Cox regressions to examine associations between changes in BMI z‐scores from 7 to 13 years of age and the subsequent risk of VTE. Among 313 998 children, 5007 girls and 5397 boys were diagnosed with VTE as adults. Compared with children with a normal BMI (25th to 75th percentile category) at both ages, children with a BMI persistently above the 75th percentile had a 1.30‐ to 1.50‐fold increased risk of VTE in adulthood. Children who experienced a BMI increase from the 25th to 75th or >75th to 90th percentile to a higher percentile category had a 1.35‐ to 1.70‐fold increased risk of adulthood VTE. Children whose BMI percentile category decreased between 7 and 13 years of age had a VTE risk similar to that of children with a persistently normal BMI. Conclusions Risk of VTE in adulthood was higher in children with a persistently above‐average BMI. Whereas weight gain from 7 to 13 years of age additionally increased VTE risk, remission from overweight by 13 years of age completely reverted the risk.https://www.ahajournals.org/doi/10.1161/JAHA.118.011407body mass indexdeep venous thrombosispulmonary embolismvenous thromboembolism |
| spellingShingle | Jens Sundbøll Lars Ängquist Kasper Adelborg Line Klingen Gjærde Anne Ording Thorkild I. A. Sørensen Jennifer L. Baker Henrik Toft Sørensen Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease body mass index deep venous thrombosis pulmonary embolism venous thromboembolism |
| title | Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood |
| title_full | Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood |
| title_fullStr | Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood |
| title_full_unstemmed | Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood |
| title_short | Changes in Childhood Body‐Mass Index and Risk of Venous Thromboembolism in Adulthood |
| title_sort | changes in childhood body mass index and risk of venous thromboembolism in adulthood |
| topic | body mass index deep venous thrombosis pulmonary embolism venous thromboembolism |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.011407 |
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