Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology
Characterizing brain activity at rest is of paramount importance to our understanding both of general principles of brain functioning and of the way brain dynamics is affected in the presence of neurological or psychiatric pathologies. We measured the time-reversal symmetry of spontaneous electroenc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.01619/full |
| _version_ | 1811331163786051584 |
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| author | Massimiliano Zanin Bahar Güntekin Bahar Güntekin Tuba Aktürk Tuba Aktürk Lütfü Hanoğlu Lütfü Hanoğlu David Papo |
| author_facet | Massimiliano Zanin Bahar Güntekin Bahar Güntekin Tuba Aktürk Tuba Aktürk Lütfü Hanoğlu Lütfü Hanoğlu David Papo |
| author_sort | Massimiliano Zanin |
| collection | DOAJ |
| description | Characterizing brain activity at rest is of paramount importance to our understanding both of general principles of brain functioning and of the way brain dynamics is affected in the presence of neurological or psychiatric pathologies. We measured the time-reversal symmetry of spontaneous electroencephalographic brain activity recorded from three groups of patients and their respective control group under two experimental conditions (eyes open and closed). We evaluated differences in time irreversibility in terms of possible underlying physical generating mechanisms. The results showed that resting brain activity is generically time-irreversible at sufficiently long time scales, and that brain pathology is generally associated with a reduction in time-asymmetry, albeit with pathology-specific patterns. The significance of these results and their possible dynamical etiology are discussed. Some implications of the differential modulation of time asymmetry by pathology and experimental condition are examined. |
| first_indexed | 2024-04-13T16:15:02Z |
| format | Article |
| id | doaj.art-8a093e03d8434f32888feb5d0e002e62 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T16:15:02Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8a093e03d8434f32888feb5d0e002e622022-12-22T02:40:05ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-01-011010.3389/fphys.2019.01619486008Time Irreversibility of Resting-State Activity in the Healthy Brain and PathologyMassimiliano Zanin0Bahar Güntekin1Bahar Güntekin2Tuba Aktürk3Tuba Aktürk4Lütfü Hanoğlu5Lütfü Hanoğlu6David Papo7Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid, SpainDepartment of Biophysics, International School of Medicine, Istanbul Medipol University, Istanbul, TurkeyREMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, TurkeyREMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, TurkeyProgram of Electroneurophysiology, Vocational School, Istanbul Medipol University, Istanbul, TurkeyREMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, TurkeyDepartment of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, TurkeyFondazione Istituto Italiano di Tecnologia, Ferrara, ItalyCharacterizing brain activity at rest is of paramount importance to our understanding both of general principles of brain functioning and of the way brain dynamics is affected in the presence of neurological or psychiatric pathologies. We measured the time-reversal symmetry of spontaneous electroencephalographic brain activity recorded from three groups of patients and their respective control group under two experimental conditions (eyes open and closed). We evaluated differences in time irreversibility in terms of possible underlying physical generating mechanisms. The results showed that resting brain activity is generically time-irreversible at sufficiently long time scales, and that brain pathology is generally associated with a reduction in time-asymmetry, albeit with pathology-specific patterns. The significance of these results and their possible dynamical etiology are discussed. Some implications of the differential modulation of time asymmetry by pathology and experimental condition are examined.https://www.frontiersin.org/article/10.3389/fphys.2019.01619/fullresting statetime irreversibilityentropy productionpermutation entropyParkinson's diseaseschizophrenia |
| spellingShingle | Massimiliano Zanin Bahar Güntekin Bahar Güntekin Tuba Aktürk Tuba Aktürk Lütfü Hanoğlu Lütfü Hanoğlu David Papo Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology Frontiers in Physiology resting state time irreversibility entropy production permutation entropy Parkinson's disease schizophrenia |
| title | Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology |
| title_full | Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology |
| title_fullStr | Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology |
| title_full_unstemmed | Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology |
| title_short | Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology |
| title_sort | time irreversibility of resting state activity in the healthy brain and pathology |
| topic | resting state time irreversibility entropy production permutation entropy Parkinson's disease schizophrenia |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.01619/full |
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