Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells

Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells

Patients with advanced prostate cancer (PCa) invariably develop resistance to anti-androgen therapy and taxane-based chemotherapy. Glucocorticoid receptor (GR) has been implicated in PCa therapy resistance; however, the mechanisms underlying GR-mediated chemoresistance remain unclear. Lens epitheliu...

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Bibliographic Details
Main Authors: Evelyn S. Sanchez-Hernandez, Pedro T. Ochoa, Tise Suzuki, Greisha L. Ortiz-Hernandez, Juli J. Unternaehrer, Hossam R. Alkashgari, Carlos J. Diaz Osterman, Shannalee R. Martinez, Zhong Chen, Isaac Kremsky, Charles Wang, Carlos A. Casiano
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
autoantibodies
chemoresistance
docetaxel
exicorilant
glucocorticoid receptor
LEDGF/p75
Online Access:https://www.mdpi.com/2073-4409/12/16/2046

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