Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.]
Angiotensin-converting enzyme I (ACE I) is a zinc-containing metallopeptidase involved in the renin-angiotensin system (RAAS) that helps in the regulation of hypertension and maintains fluid balance otherwise, which results in cardiovascular diseases (CVDs). One of the leading reasons of global deat...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1068388/full |
| _version_ | 1811217584039657472 |
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| author | Ayyagari Ramlal Aparna Nautiyal Pooja Baweja Vikash Kumar Sahil Mehta Rohit Kumar Mahto Rohit Kumar Mahto Shikha Tripathi Shikha Tripathi Aravindam Shanmugam Bingi Pujari Mallikarjuna Pushpa Raman S. K. Lal Dhandapani Raju Ambika Rajendran |
| author_facet | Ayyagari Ramlal Aparna Nautiyal Pooja Baweja Vikash Kumar Sahil Mehta Rohit Kumar Mahto Rohit Kumar Mahto Shikha Tripathi Shikha Tripathi Aravindam Shanmugam Bingi Pujari Mallikarjuna Pushpa Raman S. K. Lal Dhandapani Raju Ambika Rajendran |
| author_sort | Ayyagari Ramlal |
| collection | DOAJ |
| description | Angiotensin-converting enzyme I (ACE I) is a zinc-containing metallopeptidase involved in the renin-angiotensin system (RAAS) that helps in the regulation of hypertension and maintains fluid balance otherwise, which results in cardiovascular diseases (CVDs). One of the leading reasons of global deaths is due to CVDs. RAAS also plays a central role in maintaining homeostasis of the CV system. The commercial drugs available to treat CVDs possess several fatal side effects. Hence, phytochemicals like peptides having plant-based origin should be explored and utilized as alternative therapies. Soybean is an important leguminous crop that simultaneously possesses medicinal properties. Soybean extracts are used in many drug formulations for treating diabetes and other disorders and ailments. Soy proteins and its edible products such as tofu have shown potential inhibitory activity against ACE. Thus, this review briefly describes various soy proteins and products that can be used to inhibit ACE thereby providing new scope for the identification of potential candidates that can help in the design of safer and natural treatments for CVDs. |
| first_indexed | 2024-04-12T06:57:17Z |
| format | Article |
| id | doaj.art-8a09f2632c174c1d85dfa40961daccdf |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T06:57:17Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-8a09f2632c174c1d85dfa40961daccdf2022-12-22T03:43:07ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.10683881068388Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.]Ayyagari Ramlal0Aparna Nautiyal1Pooja Baweja2Vikash Kumar3Sahil Mehta4Rohit Kumar Mahto5Rohit Kumar Mahto6Shikha Tripathi7Shikha Tripathi8Aravindam Shanmugam9Bingi Pujari Mallikarjuna10Pushpa Raman11S. K. Lal12Dhandapani Raju13Ambika Rajendran14Division of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), New Delhi, IndiaDepartment of Botany, Deshbandhu College, University of Delhi, New Delhi, IndiaDepartment of Botany, Maitreyi College, University of Delhi, New Delhi, IndiaFaculty of Agricultural Sciences, Institute of Applied Sciences and Humanities, GLA University, Mathura, Uttar Pradesh, IndiaDepartment of Botany, Hansraj College, University of Delhi, New Delhi, IndiaDivision of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), New Delhi, IndiaSchool of Biotechnology, Institute of Science, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, IndiaIndian Council of Agricultural Research (ICAR)-National Institute for Plant Biotechnology (NIPB), New Delhi, IndiaDepartment of Botany, Institute of Science, Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, IndiaCentre for Plant Breeding and Genetics, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India0Division of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), Regional Research Centre, Dharwad, Karnataka, India1Department of Plant Breeding and Genetics, Tamil Nadu Rice Research Institute, Tamil Nadu Agricultural University, Aduthurai, Tamil Nadu, IndiaDivision of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), New Delhi, India2Division of Plant Physiology, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute, New Delhi, IndiaDivision of Genetics, Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI), New Delhi, IndiaAngiotensin-converting enzyme I (ACE I) is a zinc-containing metallopeptidase involved in the renin-angiotensin system (RAAS) that helps in the regulation of hypertension and maintains fluid balance otherwise, which results in cardiovascular diseases (CVDs). One of the leading reasons of global deaths is due to CVDs. RAAS also plays a central role in maintaining homeostasis of the CV system. The commercial drugs available to treat CVDs possess several fatal side effects. Hence, phytochemicals like peptides having plant-based origin should be explored and utilized as alternative therapies. Soybean is an important leguminous crop that simultaneously possesses medicinal properties. Soybean extracts are used in many drug formulations for treating diabetes and other disorders and ailments. Soy proteins and its edible products such as tofu have shown potential inhibitory activity against ACE. Thus, this review briefly describes various soy proteins and products that can be used to inhibit ACE thereby providing new scope for the identification of potential candidates that can help in the design of safer and natural treatments for CVDs.https://www.frontiersin.org/articles/10.3389/fnut.2022.1068388/fullsoy productsangiotensin-converting enzyme I (ACE I)cardiovascular diseases (CVDs)natural drugsrenin-angiotensin-aldosterone system (RAAS) |
| spellingShingle | Ayyagari Ramlal Aparna Nautiyal Pooja Baweja Vikash Kumar Sahil Mehta Rohit Kumar Mahto Rohit Kumar Mahto Shikha Tripathi Shikha Tripathi Aravindam Shanmugam Bingi Pujari Mallikarjuna Pushpa Raman S. K. Lal Dhandapani Raju Ambika Rajendran Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.] Frontiers in Nutrition soy products angiotensin-converting enzyme I (ACE I) cardiovascular diseases (CVDs) natural drugs renin-angiotensin-aldosterone system (RAAS) |
| title | Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.] |
| title_full | Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.] |
| title_fullStr | Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.] |
| title_full_unstemmed | Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.] |
| title_short | Angiotensin-converting enzyme inhibitory peptides and isoflavonoids from soybean [Glycine max (L.) Merr.] |
| title_sort | angiotensin converting enzyme inhibitory peptides and isoflavonoids from soybean glycine max l merr |
| topic | soy products angiotensin-converting enzyme I (ACE I) cardiovascular diseases (CVDs) natural drugs renin-angiotensin-aldosterone system (RAAS) |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1068388/full |
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