Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of China
Abstract Background Few studies have explored the prognostic role of nontraditional lipid-related indicators in non-disabling ischemic cerebrovascular events (NICE). In this study, we aimed to investigate the relationship between the ratio of non-high-density lipoprotein cholesterol to high-density...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04102-x |
| _version_ | 1797784431968124928 |
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| author | Zhongzhong Liu Xuemei Lin Lingxia Zeng Huan Zhang Weiyan Guo Qingli Lu Congli Huang Jing Wang Pei Liu Qiaoqiao Chang Mi Zhang Yan Huo Yan Wang Fang Wang Songdi Wu |
| author_facet | Zhongzhong Liu Xuemei Lin Lingxia Zeng Huan Zhang Weiyan Guo Qingli Lu Congli Huang Jing Wang Pei Liu Qiaoqiao Chang Mi Zhang Yan Huo Yan Wang Fang Wang Songdi Wu |
| author_sort | Zhongzhong Liu |
| collection | DOAJ |
| description | Abstract Background Few studies have explored the prognostic role of nontraditional lipid-related indicators in non-disabling ischemic cerebrovascular events (NICE). In this study, we aimed to investigate the relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) and the1-year risk of recurrent stroke in patients with NICE. Methods Total cholesterol (TC), HDL-C, and patient information were collected at admission. Recurrent stroke events were followed up 3, 6, and 12 months after onset. Non-HDL-C levels were calculated by subtracting HDL-C from TC. The non-HDL-C/HDL-C ratio was treated as a continuous variable and in quartiles (Q1–Q4). Stratified multivariate Cox regression was used to investigate the relationship between the non-HDL-C/HDL-C ratio and the 1-year risk of recurrent stroke in patients with NICE. Results Overall, 1,659 patients with NICE were enrolled. For each unit increase in the non-HDL-C/HDL-C ratio, the 1-year risk of recurrent stroke in patients aged ≥ 65 years (older patients) with NICE increased by 64% in the adjusted model (hazard ratio [HR]: 1.64, 95%confidence interval [CI]:1.18–2.27, P = 0.003), and the HRs were 3.21 and 4.24 times higher in the Q3 and Q4 groups than that in the Q1 group, which was considered to be the reference (adjusted model Q3: HR: 3.21, 95%CI: 1.05–9.83, P = 0.041; adjusted model Q4: HR: 4.24, 95%CI: 1.30–13.85, P = 0.017). However, there was no significant difference in patients younger than 65 years. Both curve fitting and Kaplan–Meier cumulative risk analysis showed that an elevated non-HDL-C/HDL-C ratio significantly increased the 1-year risk of recurrent stroke in older patients with NICE. The optimal range for the non-HDL-C/HDL-C ratio should be no higher than the Q2 group (2.256–2.939). Stratified Cox regression analysis showed that these results tended to be stable for different comorbidities (all P for interaction > 0.05). Conclusions Elevated non-HDL-C/HDL-C ratios significantly increased the 1-year risk of recurrent stroke in older patients with NICE. Therefore, clinicians need to pay more attention to this indicator when managing older patients with NICE. |
| first_indexed | 2024-03-13T00:39:48Z |
| format | Article |
| id | doaj.art-8a0abfbc000f429b91b3d77309045926 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-13T00:39:48Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj.art-8a0abfbc000f429b91b3d773090459262023-07-09T11:24:02ZengBMCBMC Geriatrics1471-23182023-07-0123111110.1186/s12877-023-04102-xElevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of ChinaZhongzhong Liu0Xuemei Lin1Lingxia Zeng2Huan Zhang3Weiyan Guo4Qingli Lu5Congli Huang6Jing Wang7Pei Liu8Qiaoqiao Chang9Mi Zhang10Yan Huo11Yan Wang12Fang Wang13Songdi Wu14Department of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Epidemiology and Biostatistics, School of Public Health of Xi’an Jiaotong University Health Science CenterDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityXi’an Key Laboratory for Innovation and Translation of Neuroimmunological DiseasesDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityDepartment of Neurology, Xi’an No.1 Hospital, The First Affiliated Hospital of Northwest UniversityAbstract Background Few studies have explored the prognostic role of nontraditional lipid-related indicators in non-disabling ischemic cerebrovascular events (NICE). In this study, we aimed to investigate the relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (non-HDL-C/HDL-C) and the1-year risk of recurrent stroke in patients with NICE. Methods Total cholesterol (TC), HDL-C, and patient information were collected at admission. Recurrent stroke events were followed up 3, 6, and 12 months after onset. Non-HDL-C levels were calculated by subtracting HDL-C from TC. The non-HDL-C/HDL-C ratio was treated as a continuous variable and in quartiles (Q1–Q4). Stratified multivariate Cox regression was used to investigate the relationship between the non-HDL-C/HDL-C ratio and the 1-year risk of recurrent stroke in patients with NICE. Results Overall, 1,659 patients with NICE were enrolled. For each unit increase in the non-HDL-C/HDL-C ratio, the 1-year risk of recurrent stroke in patients aged ≥ 65 years (older patients) with NICE increased by 64% in the adjusted model (hazard ratio [HR]: 1.64, 95%confidence interval [CI]:1.18–2.27, P = 0.003), and the HRs were 3.21 and 4.24 times higher in the Q3 and Q4 groups than that in the Q1 group, which was considered to be the reference (adjusted model Q3: HR: 3.21, 95%CI: 1.05–9.83, P = 0.041; adjusted model Q4: HR: 4.24, 95%CI: 1.30–13.85, P = 0.017). However, there was no significant difference in patients younger than 65 years. Both curve fitting and Kaplan–Meier cumulative risk analysis showed that an elevated non-HDL-C/HDL-C ratio significantly increased the 1-year risk of recurrent stroke in older patients with NICE. The optimal range for the non-HDL-C/HDL-C ratio should be no higher than the Q2 group (2.256–2.939). Stratified Cox regression analysis showed that these results tended to be stable for different comorbidities (all P for interaction > 0.05). Conclusions Elevated non-HDL-C/HDL-C ratios significantly increased the 1-year risk of recurrent stroke in older patients with NICE. Therefore, clinicians need to pay more attention to this indicator when managing older patients with NICE.https://doi.org/10.1186/s12877-023-04102-xNon-disabling ischemic cerebrovascular eventsLipidsOlder patientsRecurrent stroke |
| spellingShingle | Zhongzhong Liu Xuemei Lin Lingxia Zeng Huan Zhang Weiyan Guo Qingli Lu Congli Huang Jing Wang Pei Liu Qiaoqiao Chang Mi Zhang Yan Huo Yan Wang Fang Wang Songdi Wu Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of China BMC Geriatrics Non-disabling ischemic cerebrovascular events Lipids Older patients Recurrent stroke |
| title | Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of China |
| title_full | Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of China |
| title_fullStr | Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of China |
| title_full_unstemmed | Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of China |
| title_short | Elevated non-HDL-C/HDL-C ratio increases the 1-year risk of recurrent stroke in older patients with non-disabling ischemic cerebrovascular events: results from the Xi’an Stroke Registry Study of China |
| title_sort | elevated non hdl c hdl c ratio increases the 1 year risk of recurrent stroke in older patients with non disabling ischemic cerebrovascular events results from the xi an stroke registry study of china |
| topic | Non-disabling ischemic cerebrovascular events Lipids Older patients Recurrent stroke |
| url | https://doi.org/10.1186/s12877-023-04102-x |
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