Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study
Study Design This is a cross-sectional nationwide descriptive observational and analytic retrospective study. Purpose This study aims to describe and assess survival after spinal meningioma (SM) surgery. Overview of Literature A few studies report a reduced survival after SM surgery. Methods The cur...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Spine Society
2022-12-01
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| Series: | Asian Spine Journal |
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| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-2021-0213.pdf |
| _version_ | 1797961398500720640 |
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| author | Vincent Jecko Joconde Weller Deborah Houston Charles Champeaux-Depond |
| author_facet | Vincent Jecko Joconde Weller Deborah Houston Charles Champeaux-Depond |
| author_sort | Vincent Jecko |
| collection | DOAJ |
| description | Study Design This is a cross-sectional nationwide descriptive observational and analytic retrospective study. Purpose This study aims to describe and assess survival after spinal meningioma (SM) surgery. Overview of Literature A few studies report a reduced survival after SM surgery. Methods The current study processed the Système National des Données de Santé (SNDS), the French national administrative medical database, to retrieve appropriate cases. Results This study identified 2,844 patients (79.1% females) between 2008 and 2017. The median age at surgery was 66 years (interquartile range [IQR], 56–75 years). Moreover, 95.9% of SMs were removed through posterior or posterolateral approaches, and 6.9% were epidural and 0.7% needed an associated spine stabilization. Benign meningioma represented 92.9%, with 5% and 2.1% atypical and malignant, respectively. The median follow-up was 3.3 years (IQR, 3.1–3.5 years). Of the patients, 0.25% and 1.2% expired within a month and a year of surgery, respectively. At data collection, 225 patients (7.9%) expired. The 5-year overall survival (OS) probability was 90.1% (95% CI, 88.6%–91.7%). However, absolute excess risk of mortality after SM surgery was null, and the related standardized mortality ratio was 1 (95% CI, 0.9–1.2; p=0.565). In the adjusted regression, age at surgery (hazard ratio [HR], 1.06; 95% CI, 1.04–1.07; p<0.001), level of comorbidities (HR, 1.44; 95% CI, 1.34–1.54; p<0.001), neurofibromatosis type 2 (NF2; HR, 3.65; 95% CI, 1.28–10.39; p=0.0152), epidural SM (HR, 1.73; 95% CI, 1.09–2.75; p=0.0206), and malignant meningioma (HR, 2.64; 95% CI, 1.51–4.61; p<0.001) remained significantly associated to a reduced OS. Conclusions The SNDS is of great value in assessing SM incidence, associated mortality, and its predictors. OS after meningioma surgery is favorable but may be impaired for NF2 or older patients with a high level of comorbidities, epidural tumor, and malignant histopathology. SM surgery is not associated with an increased absolute excess mortality risk despite being performed on even more senior patients compared with intracranial meningioma. |
| first_indexed | 2024-04-11T00:57:47Z |
| format | Article |
| id | doaj.art-8a0be8d9b2a04d158b316134299f9314 |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-04-11T00:57:47Z |
| publishDate | 2022-12-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-8a0be8d9b2a04d158b316134299f93142023-01-04T23:59:28ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462022-12-0116686587310.31616/asj.2021.02131410Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based StudyVincent Jecko0Joconde Weller1Deborah Houston2Charles Champeaux-Depond3 Department of Neurosurgery, Pellegrin Hospital, Bordeaux, France Agence Régionale de Santé, Saint Denis, France Department of Neurosurgery, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK Department of Neurosurgery, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UKStudy Design This is a cross-sectional nationwide descriptive observational and analytic retrospective study. Purpose This study aims to describe and assess survival after spinal meningioma (SM) surgery. Overview of Literature A few studies report a reduced survival after SM surgery. Methods The current study processed the Système National des Données de Santé (SNDS), the French national administrative medical database, to retrieve appropriate cases. Results This study identified 2,844 patients (79.1% females) between 2008 and 2017. The median age at surgery was 66 years (interquartile range [IQR], 56–75 years). Moreover, 95.9% of SMs were removed through posterior or posterolateral approaches, and 6.9% were epidural and 0.7% needed an associated spine stabilization. Benign meningioma represented 92.9%, with 5% and 2.1% atypical and malignant, respectively. The median follow-up was 3.3 years (IQR, 3.1–3.5 years). Of the patients, 0.25% and 1.2% expired within a month and a year of surgery, respectively. At data collection, 225 patients (7.9%) expired. The 5-year overall survival (OS) probability was 90.1% (95% CI, 88.6%–91.7%). However, absolute excess risk of mortality after SM surgery was null, and the related standardized mortality ratio was 1 (95% CI, 0.9–1.2; p=0.565). In the adjusted regression, age at surgery (hazard ratio [HR], 1.06; 95% CI, 1.04–1.07; p<0.001), level of comorbidities (HR, 1.44; 95% CI, 1.34–1.54; p<0.001), neurofibromatosis type 2 (NF2; HR, 3.65; 95% CI, 1.28–10.39; p=0.0152), epidural SM (HR, 1.73; 95% CI, 1.09–2.75; p=0.0206), and malignant meningioma (HR, 2.64; 95% CI, 1.51–4.61; p<0.001) remained significantly associated to a reduced OS. Conclusions The SNDS is of great value in assessing SM incidence, associated mortality, and its predictors. OS after meningioma surgery is favorable but may be impaired for NF2 or older patients with a high level of comorbidities, epidural tumor, and malignant histopathology. SM surgery is not associated with an increased absolute excess mortality risk despite being performed on even more senior patients compared with intracranial meningioma.http://www.asianspinejournal.org/upload/pdf/asj-2021-0213.pdfspinal meningiomaepidemiologysurvivalrelative survivalpredictors |
| spellingShingle | Vincent Jecko Joconde Weller Deborah Houston Charles Champeaux-Depond Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study Asian Spine Journal spinal meningioma epidemiology survival relative survival predictors |
| title | Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study |
| title_full | Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study |
| title_fullStr | Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study |
| title_full_unstemmed | Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study |
| title_short | Epidemiology and Survival after Spinal Meningioma Surgery: A Nationwide Population-Based Study |
| title_sort | epidemiology and survival after spinal meningioma surgery a nationwide population based study |
| topic | spinal meningioma epidemiology survival relative survival predictors |
| url | http://www.asianspinejournal.org/upload/pdf/asj-2021-0213.pdf |
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