Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration
Growth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/2829 |
| _version_ | 1797541844638236672 |
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| author | Joaquín Guerra Gómez Jesús Devesa |
| author_facet | Joaquín Guerra Gómez Jesús Devesa |
| author_sort | Joaquín Guerra Gómez |
| collection | DOAJ |
| description | Growth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition, GH deficiency conditions hearing loss or central auditory processing disorders. There are promising animal studies that reflect a possible regenerative role when exogenous GH is used in hearing impairments, demonstrated in in vivo and in vitro studies, and also, even a few studies show beneficial effects in humans presented and substantiated in the main text, although they should not exaggerate the main conclusions. |
| first_indexed | 2024-03-10T13:21:24Z |
| format | Article |
| id | doaj.art-8a1043685cdb4d8288b219abcb19bb8b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:21:24Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8a1043685cdb4d8288b219abcb19bb8b2023-11-21T09:59:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226282910.3390/ijms22062829Growth Hormone and the Auditory Pathway: Neuromodulation and NeuroregenerationJoaquín Guerra Gómez0Jesús Devesa1Otolaryngology, Medical Center Foltra, 15886 Teo, SpainScientific Direction, Medical Center Foltra, 15886 Teo, SpainGrowth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition, GH deficiency conditions hearing loss or central auditory processing disorders. There are promising animal studies that reflect a possible regenerative role when exogenous GH is used in hearing impairments, demonstrated in in vivo and in vitro studies, and also, even a few studies show beneficial effects in humans presented and substantiated in the main text, although they should not exaggerate the main conclusions.https://www.mdpi.com/1422-0067/22/6/2829growth hormoneIGF-Icentral auditory processinghearing impairmenthereditary hearing lossGH deficiency |
| spellingShingle | Joaquín Guerra Gómez Jesús Devesa Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration International Journal of Molecular Sciences growth hormone IGF-I central auditory processing hearing impairment hereditary hearing loss GH deficiency |
| title | Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration |
| title_full | Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration |
| title_fullStr | Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration |
| title_full_unstemmed | Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration |
| title_short | Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration |
| title_sort | growth hormone and the auditory pathway neuromodulation and neuroregeneration |
| topic | growth hormone IGF-I central auditory processing hearing impairment hereditary hearing loss GH deficiency |
| url | https://www.mdpi.com/1422-0067/22/6/2829 |
| work_keys_str_mv | AT joaquinguerragomez growthhormoneandtheauditorypathwayneuromodulationandneuroregeneration AT jesusdevesa growthhormoneandtheauditorypathwayneuromodulationandneuroregeneration |