Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data

Novel insights into systemic sclerosis using a sensitive computational method to analyze whole-genome bisulfite sequencing data

Abstract Background Abnormal DNA methylation is thought to contribute to the onset and progression of systemic sclerosis. Currently, the most comprehensive assay for profiling DNA methylation is whole-genome bisulfite sequencing (WGBS), but its precision depends on read depth and it may be subject t...

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Bibliographic Details
Main Authors: Jeffrey C. Y. Yu, Yixiao Zeng, Kaiqiong Zhao, Tianyuan Lu, Kathleen Oros Klein, Inés Colmegna, Maximilien Lora, Sahir R. Bhatnagar, Andrew Leask, Celia M. T. Greenwood, Marie Hudson
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Clinical Epigenetics
Subjects:
Scleroderma
Systemic sclerosis
DNA methylation
Whole genome bisulfite sequencing
Differentially methylated regions
Smoothing
Online Access:https://doi.org/10.1186/s13148-023-01513-w

Internet

https://doi.org/10.1186/s13148-023-01513-w

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