Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza
Salvia miltiorrhiza Bunge is a common Chinese herbal medicine, and its major active ingredients are phenolic acids and tanshinones, which are widely used to treat vascular diseases. However, the wild form of S. miltiorrhiza possess low levels of these important pharmaceutical agents; thus, improving...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2021.622011/full |
| _version_ | 1819173744955883520 |
|---|---|
| author | Sijia Wu Bo Zhu Luping Qin Khalid Rahman Lei Zhang Ting Han |
| author_facet | Sijia Wu Bo Zhu Luping Qin Khalid Rahman Lei Zhang Ting Han |
| author_sort | Sijia Wu |
| collection | DOAJ |
| description | Salvia miltiorrhiza Bunge is a common Chinese herbal medicine, and its major active ingredients are phenolic acids and tanshinones, which are widely used to treat vascular diseases. However, the wild form of S. miltiorrhiza possess low levels of these important pharmaceutical agents; thus, improving their levels is an active area of research. Transcription factors, which promote or inhibit the expressions of multiple genes involved in one or more biosynthetic pathways, are powerful tools for controlling gene expression in biosynthesis. Several families of transcription factors have been reported to participate in regulating phenolic acid and tanshinone biosynthesis and influence their accumulation. This review summarizes the current status in this field, with focus on the transcription factors which have been identified in recent years and their functions in the biosynthetic regulation of phenolic acids and tanshinones. Otherwise, the new insight for further research is provided. Finally, the application of the biosynthetic regulation of active ingredients by the transcription factors in S. miltiorrhiza are discussed, and new insights for future research are explored. |
| first_indexed | 2024-12-22T20:27:57Z |
| format | Article |
| id | doaj.art-8a10acbcc0f04e2882985a4676037d5a |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-22T20:27:57Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-8a10acbcc0f04e2882985a4676037d5a2022-12-21T18:13:41ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2021-02-011210.3389/fpls.2021.622011622011Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhizaSijia Wu0Bo Zhu1Luping Qin2Khalid Rahman3Lei Zhang4Ting Han5School of Pharmacy, Second Military Medical University, Shanghai, ChinaSchool of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, ChinaFaculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United KingdomSchool of Pharmacy, Second Military Medical University, Shanghai, ChinaSchool of Pharmacy, Second Military Medical University, Shanghai, ChinaSalvia miltiorrhiza Bunge is a common Chinese herbal medicine, and its major active ingredients are phenolic acids and tanshinones, which are widely used to treat vascular diseases. However, the wild form of S. miltiorrhiza possess low levels of these important pharmaceutical agents; thus, improving their levels is an active area of research. Transcription factors, which promote or inhibit the expressions of multiple genes involved in one or more biosynthetic pathways, are powerful tools for controlling gene expression in biosynthesis. Several families of transcription factors have been reported to participate in regulating phenolic acid and tanshinone biosynthesis and influence their accumulation. This review summarizes the current status in this field, with focus on the transcription factors which have been identified in recent years and their functions in the biosynthetic regulation of phenolic acids and tanshinones. Otherwise, the new insight for further research is provided. Finally, the application of the biosynthetic regulation of active ingredients by the transcription factors in S. miltiorrhiza are discussed, and new insights for future research are explored.https://www.frontiersin.org/articles/10.3389/fpls.2021.622011/fullSalvia miltiorrhizatranscription factorbiosynthetic regulationtanshinonesphenolic acids |
| spellingShingle | Sijia Wu Bo Zhu Luping Qin Khalid Rahman Lei Zhang Ting Han Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza Frontiers in Plant Science Salvia miltiorrhiza transcription factor biosynthetic regulation tanshinones phenolic acids |
| title | Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza |
| title_full | Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza |
| title_fullStr | Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza |
| title_full_unstemmed | Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza |
| title_short | Transcription Factor: A Powerful Tool to Regulate Biosynthesis of Active Ingredients in Salvia miltiorrhiza |
| title_sort | transcription factor a powerful tool to regulate biosynthesis of active ingredients in salvia miltiorrhiza |
| topic | Salvia miltiorrhiza transcription factor biosynthetic regulation tanshinones phenolic acids |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2021.622011/full |
| work_keys_str_mv | AT sijiawu transcriptionfactorapowerfultooltoregulatebiosynthesisofactiveingredientsinsalviamiltiorrhiza AT bozhu transcriptionfactorapowerfultooltoregulatebiosynthesisofactiveingredientsinsalviamiltiorrhiza AT lupingqin transcriptionfactorapowerfultooltoregulatebiosynthesisofactiveingredientsinsalviamiltiorrhiza AT khalidrahman transcriptionfactorapowerfultooltoregulatebiosynthesisofactiveingredientsinsalviamiltiorrhiza AT leizhang transcriptionfactorapowerfultooltoregulatebiosynthesisofactiveingredientsinsalviamiltiorrhiza AT tinghan transcriptionfactorapowerfultooltoregulatebiosynthesisofactiveingredientsinsalviamiltiorrhiza |