Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients
Introduction. Hemodialysis patients are the group which oxidative stress is found more exacerbated. Ischemia modified albumin (IMA) is a new and sensitive marker for ischemia and oxidative stress. At current study we evaluated relation between IMA and biochemical parameters in hemodialysis patients...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-01-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | https://www.italjmed.org/index.php/ijm/article/view/1560 |
| _version_ | 1797426485770846208 |
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| author | Kenan Güçlü Kağan Tur Serdar Şahin Aydın Güçlü |
| author_facet | Kenan Güçlü Kağan Tur Serdar Şahin Aydın Güçlü |
| author_sort | Kenan Güçlü |
| collection | DOAJ |
| description |
Introduction. Hemodialysis patients are the group which oxidative stress is found more exacerbated. Ischemia modified albumin (IMA) is a new and sensitive marker for ischemia and oxidative stress. At current study we evaluated relation between IMA and biochemical parameters in hemodialysis patients.
Materials and Methods. Thirty-four patients on maintenance hemodialysis were included. Pre-hemodialysis and post-hemodialysis blood samples were taken. Serum IMA and biochemistry parameters were measured.
Results. There was a positive correlation between alkaline phosphatase (ALP) and IMA (r=0,268, p<0,05), CRP and IMA (r=0,452, p=0,007), parathormone and IMA (r=0,436, p=0,010), There was a negative correlation between albumin and IMA (r=-0,338, p=0,05). Multiple regression analysis was run to predict IMA levels from parathormone, CRP and creatinine the model statistically significantly predicted relation p<0,05, R=0,506, out of four two variables added statistically significant to the prediction, PTH (p=0,006), CRP (p=0,029). In multiregression analysis, IMA was found to be associated with PTH and CRP independent of creatinine value.
Conclusions. We showed for the first time that PTH is associated with IMA in hemodialysis patients, independent of the level of renal function.
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| first_indexed | 2024-03-09T08:30:52Z |
| format | Article |
| id | doaj.art-8a110e76ee3e420b964df0af5e129fa1 |
| institution | Directory Open Access Journal |
| issn | 1877-9344 1877-9352 |
| language | English |
| last_indexed | 2024-03-09T08:30:52Z |
| publishDate | 2023-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj.art-8a110e76ee3e420b964df0af5e129fa12023-12-02T20:12:44ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522023-01-01AOP10.4081/itjm.2022.1560Independent correlation between ischemia modified albumin and parathormone in hemodialysis patientsKenan Güçlü0Kağan Tur1Serdar Şahin2Aydın Güçlü3Kayseri State Hospital Biochemistry Department, Kayseri, TURKEYAhi Evran University Faculty of Medicine, Internal Medicine Department, Kırşehir, TURKEYAhi Evran University Faculty of Medicine, General Surgery Department, Kırşehir, Turkey,Ahi Evran University Faculty of Medicine, Nephrology Department, Kırşehir, TURKEY Introduction. Hemodialysis patients are the group which oxidative stress is found more exacerbated. Ischemia modified albumin (IMA) is a new and sensitive marker for ischemia and oxidative stress. At current study we evaluated relation between IMA and biochemical parameters in hemodialysis patients. Materials and Methods. Thirty-four patients on maintenance hemodialysis were included. Pre-hemodialysis and post-hemodialysis blood samples were taken. Serum IMA and biochemistry parameters were measured. Results. There was a positive correlation between alkaline phosphatase (ALP) and IMA (r=0,268, p<0,05), CRP and IMA (r=0,452, p=0,007), parathormone and IMA (r=0,436, p=0,010), There was a negative correlation between albumin and IMA (r=-0,338, p=0,05). Multiple regression analysis was run to predict IMA levels from parathormone, CRP and creatinine the model statistically significantly predicted relation p<0,05, R=0,506, out of four two variables added statistically significant to the prediction, PTH (p=0,006), CRP (p=0,029). In multiregression analysis, IMA was found to be associated with PTH and CRP independent of creatinine value. Conclusions. We showed for the first time that PTH is associated with IMA in hemodialysis patients, independent of the level of renal function. https://www.italjmed.org/index.php/ijm/article/view/1560ischemia modified albumin, hemodialysis, oxidative stress, chronic kidney disease-bone mineral disease, parathormone |
| spellingShingle | Kenan Güçlü Kağan Tur Serdar Şahin Aydın Güçlü Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients Italian Journal of Medicine ischemia modified albumin, hemodialysis, oxidative stress, chronic kidney disease-bone mineral disease, parathormone |
| title | Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients |
| title_full | Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients |
| title_fullStr | Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients |
| title_full_unstemmed | Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients |
| title_short | Independent correlation between ischemia modified albumin and parathormone in hemodialysis patients |
| title_sort | independent correlation between ischemia modified albumin and parathormone in hemodialysis patients |
| topic | ischemia modified albumin, hemodialysis, oxidative stress, chronic kidney disease-bone mineral disease, parathormone |
| url | https://www.italjmed.org/index.php/ijm/article/view/1560 |
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