LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

Abstract Background The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for...

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Bibliographic Details
Main Authors: Ø. Salvesen, M. R. Reiten, A. Espenes, M. K. Bakkebø, M. A. Tranulis, C. Ersdal
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Journal of Neuroinflammation
Subjects:
Cellular prion protein
Systemic inflammation
Lipopolysaccharide (LPS)
Innate immunity
Choroid plexus
Hippocampus
Online Access:http://link.springer.com/article/10.1186/s12974-017-0879-5

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