Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering
Abstract Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tens...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2013-01-01
|
| Series: | Nanomedicine Journal |
| Subjects: | |
| Online Access: | http://nmj.mums.ac.ir/?_action=showPDF&article=699&_ob=e128a17b28b681c1188113d94dc793f5&fileName=full_text.pdf |
| _version_ | 1819012331805343744 |
|---|---|
| author | Masoud Soleimani Ebrahim Vasheghani-Farahani Amir Doustgani |
| author_facet | Masoud Soleimani Ebrahim Vasheghani-Farahani Amir Doustgani |
| author_sort | Masoud Soleimani |
| collection | DOAJ |
| description | Abstract Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 32 nm and 339 ± 107 nm for aligned and random nanofibers, respectively. The mechanical data indicated the higher tensile strength and elastic modulus of aligned nanofibers. The in vitro biocompatibility of aligned and random nanofibrous scaffolds was also assessed by growing mesenchymal stem cells (MSCs), and investigating the proliferation and alkaline phosphatase activity (ALP) on different nanofibrous scaffolds. Our findings showed that the alignment orientation of nanofibers enhanced the osteogenic differentiation of stem cells. The in vitro results showed that the aligned biocomposite nanofibrous scaffolds of PCL/nHA/PVA could be a potential substrate for tissue engineering applications, especially in the field of artificial bone implant. |
| first_indexed | 2024-12-21T01:42:22Z |
| format | Article |
| id | doaj.art-8a11eead084b4d01b36eb467510d7464 |
| institution | Directory Open Access Journal |
| issn | 2322-3049 2322-5904 |
| language | English |
| last_indexed | 2024-12-21T01:42:22Z |
| publishDate | 2013-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj.art-8a11eead084b4d01b36eb467510d74642022-12-21T19:20:07ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042013-01-01112027Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineeringMasoud SoleimaniEbrahim Vasheghani-FarahaniAmir DoustganiAbstract Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 32 nm and 339 ± 107 nm for aligned and random nanofibers, respectively. The mechanical data indicated the higher tensile strength and elastic modulus of aligned nanofibers. The in vitro biocompatibility of aligned and random nanofibrous scaffolds was also assessed by growing mesenchymal stem cells (MSCs), and investigating the proliferation and alkaline phosphatase activity (ALP) on different nanofibrous scaffolds. Our findings showed that the alignment orientation of nanofibers enhanced the osteogenic differentiation of stem cells. The in vitro results showed that the aligned biocomposite nanofibrous scaffolds of PCL/nHA/PVA could be a potential substrate for tissue engineering applications, especially in the field of artificial bone implant.http://nmj.mums.ac.ir/?_action=showPDF&article=699&_ob=e128a17b28b681c1188113d94dc793f5&fileName=full_text.pdfElectrospinningNanofibersBone tissue engineering |
| spellingShingle | Masoud Soleimani Ebrahim Vasheghani-Farahani Amir Doustgani Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering Nanomedicine Journal Electrospinning Nanofibers Bone tissue engineering |
| title | Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering |
| title_full | Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering |
| title_fullStr | Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering |
| title_full_unstemmed | Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering |
| title_short | Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering |
| title_sort | aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering |
| topic | Electrospinning Nanofibers Bone tissue engineering |
| url | http://nmj.mums.ac.ir/?_action=showPDF&article=699&_ob=e128a17b28b681c1188113d94dc793f5&fileName=full_text.pdf |
| work_keys_str_mv | AT masoudsoleimani alignedandrandomnanofibrousnanocompositescaffoldsforbonetissueengineering AT ebrahimvasheghanifarahani alignedandrandomnanofibrousnanocompositescaffoldsforbonetissueengineering AT amirdoustgani alignedandrandomnanofibrousnanocompositescaffoldsforbonetissueengineering |