Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability

Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability

Abstract Septic shock is characterized by dysregulated vascular permeability. We hypothesized that the vascular permeability of endothelial cells (ECs) would be regulated by serotonin via serotonin-Rho-associated kinase (ROCK) signaling. We aimed to determine the impact of 5-hydroxyindoleacetic acid...

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Bibliographic Details
Main Authors: Takeshi Tanaka, Masahiko Mori, Motohiro Sekino, Ushio Higashijima, Masahiro Takaki, Yoshiro Yamashita, Satoshi Kakiuchi, Masato Tashiro, Konosuke Morimoto, Osamu Tasaki, Koichi Izumikawa
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93649-z

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