Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino rats
This study investigated the hematological parameters and renal function effects of Flunixin Meglumine (FM) and assessed the potential protective role of Alpha lipoic acid (ALA) in male rats. Hematological studies, kidney function tests, oxidative stress and antioxidant capacities, kidney weights an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Assiut University
2024-04-01
|
| Series: | Journal of Advanced Veterinary Research |
| Subjects: | |
| Online Access: | https://advetresearch.com/index.php/AVR/article/view/1737 |
| _version_ | 1797224069675876352 |
|---|---|
| author | Zeynab K. El-Maddawy Abd El-Salam F. El-Sawy Amal A. Awad |
| author_facet | Zeynab K. El-Maddawy Abd El-Salam F. El-Sawy Amal A. Awad |
| author_sort | Zeynab K. El-Maddawy |
| collection | DOAJ |
| description |
This study investigated the hematological parameters and renal function effects of Flunixin Meglumine (FM) and assessed the potential protective role of Alpha lipoic acid (ALA) in male rats. Hematological studies, kidney function tests, oxidative stress and antioxidant capacities, kidney weights and index weights, and histopathological studies were evaluated on the 4th and 8th weeks of the experiment. The experiment involved administering FM for 14 successive days and ALA for 56 successive days. Seventy-two (72) male rats were randomly divided into six groups (n=12 animals each): Group 1 (control) received saline and distilled water, Group 2 (ALA) received ALA at a dose level 100mg/kg bwt orally, Group 3 (FM-2.5) received Flunixin meglumine at a dose level (2.5mg/kg bwt) subcutaneously, Group 4 (FM-5) received FM subcutaneously, Group 5 (FM-2.5 and ALA) received FM and ALA, and Group 6 (FM-5 and ALA) received FM and ALA. Flunixin meglumine increased WBCs, serum urea and creatinine levels, MDA, some histopathological changes in kidney tissue, and decreased TAC. These alterations were mitigated by addition of alpha lipoic acid. Non-significant changes in Hb%, P.C.V.%, RBCs and kidney index weight among all treated and control groups. In conclusion, the administration of FM induced hematological and renal impairments in male rats. However, co-administration of ALA effectively mitigated these impairments, suggesting its potential protective role against FM-induced hematological and renal disturbances.
|
| first_indexed | 2024-04-24T13:47:16Z |
| format | Article |
| id | doaj.art-8a13a76e9a3048899b5f8705525f3003 |
| institution | Directory Open Access Journal |
| issn | 2090-6269 2090-6277 |
| language | English |
| last_indexed | 2024-04-24T13:47:16Z |
| publishDate | 2024-04-01 |
| publisher | Assiut University |
| record_format | Article |
| series | Journal of Advanced Veterinary Research |
| spelling | doaj.art-8a13a76e9a3048899b5f8705525f30032024-04-04T05:13:13ZengAssiut UniversityJournal of Advanced Veterinary Research2090-62692090-62772024-04-01144Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino ratsZeynab K. El-Maddawy0Abd El-Salam F. El-Sawy1Amal A. Awad2Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Alexandria University, Alexandria governorate, Egypt.Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Alexandria University, Alexandria governorate, Egypt.Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Alexandria University, Alexandria governorate, Egypt. This study investigated the hematological parameters and renal function effects of Flunixin Meglumine (FM) and assessed the potential protective role of Alpha lipoic acid (ALA) in male rats. Hematological studies, kidney function tests, oxidative stress and antioxidant capacities, kidney weights and index weights, and histopathological studies were evaluated on the 4th and 8th weeks of the experiment. The experiment involved administering FM for 14 successive days and ALA for 56 successive days. Seventy-two (72) male rats were randomly divided into six groups (n=12 animals each): Group 1 (control) received saline and distilled water, Group 2 (ALA) received ALA at a dose level 100mg/kg bwt orally, Group 3 (FM-2.5) received Flunixin meglumine at a dose level (2.5mg/kg bwt) subcutaneously, Group 4 (FM-5) received FM subcutaneously, Group 5 (FM-2.5 and ALA) received FM and ALA, and Group 6 (FM-5 and ALA) received FM and ALA. Flunixin meglumine increased WBCs, serum urea and creatinine levels, MDA, some histopathological changes in kidney tissue, and decreased TAC. These alterations were mitigated by addition of alpha lipoic acid. Non-significant changes in Hb%, P.C.V.%, RBCs and kidney index weight among all treated and control groups. In conclusion, the administration of FM induced hematological and renal impairments in male rats. However, co-administration of ALA effectively mitigated these impairments, suggesting its potential protective role against FM-induced hematological and renal disturbances. https://advetresearch.com/index.php/AVR/article/view/1737Flunixin MeglumineAlpha Lipoic AcidHematological parametersRenal functionantioxidant activity |
| spellingShingle | Zeynab K. El-Maddawy Abd El-Salam F. El-Sawy Amal A. Awad Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino rats Journal of Advanced Veterinary Research Flunixin Meglumine Alpha Lipoic Acid Hematological parameters Renal function antioxidant activity |
| title | Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino rats |
| title_full | Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino rats |
| title_fullStr | Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino rats |
| title_full_unstemmed | Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino rats |
| title_short | Mitigating effect of alpha lipoic acid against hematological and renal impairments induced by Flunixin meglumine in male albino rats |
| title_sort | mitigating effect of alpha lipoic acid against hematological and renal impairments induced by flunixin meglumine in male albino rats |
| topic | Flunixin Meglumine Alpha Lipoic Acid Hematological parameters Renal function antioxidant activity |
| url | https://advetresearch.com/index.php/AVR/article/view/1737 |
| work_keys_str_mv | AT zeynabkelmaddawy mitigatingeffectofalphalipoicacidagainsthematologicalandrenalimpairmentsinducedbyflunixinmeglumineinmalealbinorats AT abdelsalamfelsawy mitigatingeffectofalphalipoicacidagainsthematologicalandrenalimpairmentsinducedbyflunixinmeglumineinmalealbinorats AT amalaawad mitigatingeffectofalphalipoicacidagainsthematologicalandrenalimpairmentsinducedbyflunixinmeglumineinmalealbinorats |