Leonurine Improves Age-Dependent Impaired Angiogenesis: Possible Involvement of Mitochondrial Function and HIF-1α Dependent VEGF Activation

Leonurine Improves Age-Dependent Impaired Angiogenesis: Possible Involvement of Mitochondrial Function and HIF-1α Dependent VEGF Activation

Objective: Advanced age is associated with impaired angiogenesis in part because of mitochondrial dysfunction. We have recently reported that leonurine exerts protective effects in neuron via regulation of mitochondrial function. The aim of this study was to explore whether leonurine is able to atte...

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Bibliographic Details
Main Authors: Jia Qi, Jing J. Wang, Jun L. Duan, Zhao Y. Lu, Yang G. Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
leonurine
mitochondrial dysfunction
angiogenesis
hindlimb ischemia
age
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00284/full

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