Herpesvirus and neurological manifestations in patients with severe coronavirus disease
Abstract Background Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes an...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
|
| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-022-01828-9 |
| _version_ | 1818207318942154752 |
|---|---|
| author | Vanessa Cristine de Souza Carneiro Soniza Vieira Alves-Leon Dmitry José de Santana Sarmento Wagner Luis da Costa Nunes Pimentel Coelho Otacilio da Cruz Moreira Andreza Lemos Salvio Carlos Henrique Ferreira Ramos Carlos Henrique Ferreira Ramos Filho Carla Augusta Barreto Marques João Paulo da Costa Gonçalves Luciane Almeida Amado Leon Vanessa Salete de Paula |
| author_facet | Vanessa Cristine de Souza Carneiro Soniza Vieira Alves-Leon Dmitry José de Santana Sarmento Wagner Luis da Costa Nunes Pimentel Coelho Otacilio da Cruz Moreira Andreza Lemos Salvio Carlos Henrique Ferreira Ramos Carlos Henrique Ferreira Ramos Filho Carla Augusta Barreto Marques João Paulo da Costa Gonçalves Luciane Almeida Amado Leon Vanessa Salete de Paula |
| author_sort | Vanessa Cristine de Souza Carneiro |
| collection | DOAJ |
| description | Abstract Background Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms. Methods We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method. Results Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034). Conclusions The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection. |
| first_indexed | 2024-12-12T04:27:01Z |
| format | Article |
| id | doaj.art-8a16987c3d024a7aba995df90ffd5693 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-12T04:27:01Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-8a16987c3d024a7aba995df90ffd56932022-12-22T00:38:11ZengBMCVirology Journal1743-422X2022-06-011911910.1186/s12985-022-01828-9Herpesvirus and neurological manifestations in patients with severe coronavirus diseaseVanessa Cristine de Souza Carneiro0Soniza Vieira Alves-Leon1Dmitry José de Santana Sarmento2Wagner Luis da Costa Nunes Pimentel Coelho3Otacilio da Cruz Moreira4Andreza Lemos Salvio5Carlos Henrique Ferreira Ramos6Carlos Henrique Ferreira Ramos Filho7Carla Augusta Barreto Marques8João Paulo da Costa Gonçalves9Luciane Almeida Amado Leon10Vanessa Salete de Paula11Laboratory of Molecular Virology, Oswaldo Cruz Institute/FiocruzDepartment of Neurology/Reference and Research Center for Multiple Sclerosisand Other Central Nervous System Idiopathic Demyelinating Inflammatory Diseases, Clementino Fraga Filho University Hospital, Federal University of Rio de JaneiroDepartment of Oral Diagnosis, School of Dentistry, State University of ParaíbaLaboratory of Technological Development in Virology, Oswaldo Cruz Institute/FiocruzLaboratory of Molecular Virology, Oswaldo Cruz Institute/FiocruzLaboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIOLaboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIOLaboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIOLaboratory of Translacional Neurosciences, Biomedical Institute, Federal University of the State of Rio de Janeiro/UNIRIODepartment of Neurology/Reference and Research Center for Multiple Sclerosisand Other Central Nervous System Idiopathic Demyelinating Inflammatory Diseases, Clementino Fraga Filho University Hospital, Federal University of Rio de JaneiroLaboratory of Technological Development in Virology, Oswaldo Cruz Institute/FiocruzLaboratory of Molecular Virology, Oswaldo Cruz Institute/FiocruzAbstract Background Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms. Methods We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method. Results Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034). Conclusions The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.https://doi.org/10.1186/s12985-022-01828-9SARS-CoV-2 infectionHerpesvirusNeurological manifestations |
| spellingShingle | Vanessa Cristine de Souza Carneiro Soniza Vieira Alves-Leon Dmitry José de Santana Sarmento Wagner Luis da Costa Nunes Pimentel Coelho Otacilio da Cruz Moreira Andreza Lemos Salvio Carlos Henrique Ferreira Ramos Carlos Henrique Ferreira Ramos Filho Carla Augusta Barreto Marques João Paulo da Costa Gonçalves Luciane Almeida Amado Leon Vanessa Salete de Paula Herpesvirus and neurological manifestations in patients with severe coronavirus disease Virology Journal SARS-CoV-2 infection Herpesvirus Neurological manifestations |
| title | Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_full | Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_fullStr | Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_full_unstemmed | Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_short | Herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| title_sort | herpesvirus and neurological manifestations in patients with severe coronavirus disease |
| topic | SARS-CoV-2 infection Herpesvirus Neurological manifestations |
| url | https://doi.org/10.1186/s12985-022-01828-9 |
| work_keys_str_mv | AT vanessacristinedesouzacarneiro herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT sonizavieiraalvesleon herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT dmitryjosedesantanasarmento herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT wagnerluisdacostanunespimentelcoelho herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT otaciliodacruzmoreira herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT andrezalemossalvio herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT carloshenriqueferreiraramos herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT carloshenriqueferreiraramosfilho herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT carlaaugustabarretomarques herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT joaopaulodacostagoncalves herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT lucianealmeidaamadoleon herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease AT vanessasaletedepaula herpesvirusandneurologicalmanifestationsinpatientswithseverecoronavirusdisease |