CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings
The real burden of community-acquired pneumonia (CAP) in non-hospitalized patients is largely unknown. This is a 3-year prospective, observational study of ambulatory CAP in adults, conducted in 24 Spanish primary care centers between 2016–2019. Sociodemographic and clinical variables of patients wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/3/508 |
| _version_ | 1797417018870202368 |
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| author | Jesús Molina Amelia González-Gamarra Leovigildo Ginel Mª Encarnación Peláez Juan Luis Juez Antonio Artuñedo Gonzalo Aldana Enriqueta Quesada Joan Josep Cabré Antonio Gómez Manuel Linares Maria Teresa Marín Pilar Yolanda Sanchez Leonor Núñez Jaime Gonzálvez Enrique Mascarós Javier López Agustina Cano José Herrero María Carmen Serra Enrique Cimas Marta Pedrol Juan Vicente Alfaro Federico Martinón-Torres Isabel Cifuentes Cristina Méndez Daniel Ocaña on behalf of the CAPPRIC study group |
| author_facet | Jesús Molina Amelia González-Gamarra Leovigildo Ginel Mª Encarnación Peláez Juan Luis Juez Antonio Artuñedo Gonzalo Aldana Enriqueta Quesada Joan Josep Cabré Antonio Gómez Manuel Linares Maria Teresa Marín Pilar Yolanda Sanchez Leonor Núñez Jaime Gonzálvez Enrique Mascarós Javier López Agustina Cano José Herrero María Carmen Serra Enrique Cimas Marta Pedrol Juan Vicente Alfaro Federico Martinón-Torres Isabel Cifuentes Cristina Méndez Daniel Ocaña on behalf of the CAPPRIC study group |
| author_sort | Jesús Molina |
| collection | DOAJ |
| description | The real burden of community-acquired pneumonia (CAP) in non-hospitalized patients is largely unknown. This is a 3-year prospective, observational study of ambulatory CAP in adults, conducted in 24 Spanish primary care centers between 2016–2019. Sociodemographic and clinical variables of patients with radiographically confirmed CAP were collected. Pneumococcal etiology was assessed using the Binax Now<sup>®</sup> test. Patients were followed up for 10 ± 3 days. A total of 456 CAP patients were included in the study. Mean age was 56.6 (±17.5) years, 53.5% were female, and 53.9% had ≥1 comorbidity. Average incidence of CAP was 1.2–3.5 cases per 1000 persons per year. Eighteen patients (3.9%) were classified as pneumococcal CAP. Cough was present in 88.1% of patients at diagnosis and fever in 70.8%. Increased pulmonary density (63.3%) and alveolar infiltrates with air bronchogram (16.6%) were the most common radiographic findings. After 14.6 ± 6.0 days (95% CI = 13.9–15.3), 65.4% of patients had recovered. Hospitalization rate was 2.8%. The most frequently prescribed antibiotics were quinolones (58.7%) and β-lactams (31.1%). In conclusion, one-third of CAP patients did not fully recover after two weeks of empiric antibiotic therapy and 2.8% required hospitalization, highlighting the significant burden associated with non-hospitalized CAP in Spain. |
| first_indexed | 2024-03-09T06:12:47Z |
| format | Article |
| id | doaj.art-8a174717889e4af9a6bda0ecc915b118 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T06:12:47Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-8a174717889e4af9a6bda0ecc915b1182023-12-03T11:56:58ZengMDPI AGMicroorganisms2076-26072021-02-019350810.3390/microorganisms9030508CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care SettingsJesús Molina0Amelia González-Gamarra1Leovigildo Ginel2Mª Encarnación Peláez3Juan Luis Juez4Antonio Artuñedo5Gonzalo Aldana6Enriqueta Quesada7Joan Josep Cabré8Antonio Gómez9Manuel Linares10Maria Teresa Marín11Pilar Yolanda Sanchez12Leonor Núñez13Jaime Gonzálvez14Enrique Mascarós15Javier López16Agustina Cano17José Herrero18María Carmen Serra19Enrique Cimas20Marta Pedrol21Juan Vicente Alfaro22Federico Martinón-Torres23Isabel Cifuentes24Cristina Méndez25Daniel Ocaña26on behalf of the CAPPRIC study groupPrimary Health Care Center Francia, Fuenlabrada, 28943 Madrid, SpainPrimary Health Care Center Goya, 28009 Madrid, SpainPrimary Health Care Center Ciudad Jardín, 29014 Málaga, SpainPrimary Health Care Center Puerta Blanca, 29004 Málaga, SpainPrimary Health Care Center Urban, 48901 Barakaldo, SpainPrimary Health Care Center Nova Lloreda, 08917 Badalona, SpainPrimary Health Care Center Burriana II, 12530 Burriana, SpainPrimary Health Care Service, Hospital de Alta Resolución “El Toyo”, 04131 Almería, SpainPrimary Health Care Center Sant Pere, 43202 Reus, SpainPrimary Health Care Center Fernando el Católico, 50009 Zaragoza, SpainPrimary Health Care Center Buenos Aires, 28038 Madrid, SpainPrimary Health Care Center General Ricardos, 28019 Madrid, SpainPrimary Health Care Center Actur Sur, 50018 Zaragoza, SpainPrimary Health Care Center Barrio de la Salud, 38007 Santa Cruz de Tenerife, SpainPrimary Health Care Center Matamá, 36312 Vigo, SpainPrimary Health Care Center Fuente San Luis, 46013 Valencia, SpainPrimary Health Care Center Utrera Norte Príncipe de Asturias, 41710 Utrera, SpainPrimary Health Care Center García Noblejas, 28037 Madrid, SpainPrimary Health Care Center Los Comuneros, 09006 Burgos, SpainPrimary Health Care Center Just Ramírez, 46009 Valencia, SpainPrimary Health Care Center Contrueces, 33210 Gijón, SpainPrimary Health Care Center Sant Llàtzer, 08221 Terrasa, SpainPrimary Health Care Center Murcia Centro-San Juan, 30003 Murcia, SpainGenetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP), Healthcare Research Institute of Santiago de Compostela, 15706 Santiago de Compostela, SpainMedical Department, Pfizer S.L.U., Alcobendas, 28108 Madrid, SpainMedical Department, Pfizer S.L.U., Alcobendas, 28108 Madrid, SpainPrimary Health Care Center Algeciras-Norte, 11205 Algeciras, SpainThe real burden of community-acquired pneumonia (CAP) in non-hospitalized patients is largely unknown. This is a 3-year prospective, observational study of ambulatory CAP in adults, conducted in 24 Spanish primary care centers between 2016–2019. Sociodemographic and clinical variables of patients with radiographically confirmed CAP were collected. Pneumococcal etiology was assessed using the Binax Now<sup>®</sup> test. Patients were followed up for 10 ± 3 days. A total of 456 CAP patients were included in the study. Mean age was 56.6 (±17.5) years, 53.5% were female, and 53.9% had ≥1 comorbidity. Average incidence of CAP was 1.2–3.5 cases per 1000 persons per year. Eighteen patients (3.9%) were classified as pneumococcal CAP. Cough was present in 88.1% of patients at diagnosis and fever in 70.8%. Increased pulmonary density (63.3%) and alveolar infiltrates with air bronchogram (16.6%) were the most common radiographic findings. After 14.6 ± 6.0 days (95% CI = 13.9–15.3), 65.4% of patients had recovered. Hospitalization rate was 2.8%. The most frequently prescribed antibiotics were quinolones (58.7%) and β-lactams (31.1%). In conclusion, one-third of CAP patients did not fully recover after two weeks of empiric antibiotic therapy and 2.8% required hospitalization, highlighting the significant burden associated with non-hospitalized CAP in Spain.https://www.mdpi.com/2076-2607/9/3/508CAPambulatorynon-hospitalizedoutpatientpneumococcal CAPcommunity-acquired pneumonia |
| spellingShingle | Jesús Molina Amelia González-Gamarra Leovigildo Ginel Mª Encarnación Peláez Juan Luis Juez Antonio Artuñedo Gonzalo Aldana Enriqueta Quesada Joan Josep Cabré Antonio Gómez Manuel Linares Maria Teresa Marín Pilar Yolanda Sanchez Leonor Núñez Jaime Gonzálvez Enrique Mascarós Javier López Agustina Cano José Herrero María Carmen Serra Enrique Cimas Marta Pedrol Juan Vicente Alfaro Federico Martinón-Torres Isabel Cifuentes Cristina Méndez Daniel Ocaña on behalf of the CAPPRIC study group CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings Microorganisms CAP ambulatory non-hospitalized outpatient pneumococcal CAP community-acquired pneumonia |
| title | CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings |
| title_full | CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings |
| title_fullStr | CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings |
| title_full_unstemmed | CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings |
| title_short | CAPPRIC Study—Characterization of Community-Acquired Pneumonia in Spanish Adults Managed in Primary Care Settings |
| title_sort | cappric study characterization of community acquired pneumonia in spanish adults managed in primary care settings |
| topic | CAP ambulatory non-hospitalized outpatient pneumococcal CAP community-acquired pneumonia |
| url | https://www.mdpi.com/2076-2607/9/3/508 |
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