Small Molecule-Based Enzyme Inhibitors in the Treatment of Primary Hyperoxalurias

Small Molecule-Based Enzyme Inhibitors in the Treatment of Primary Hyperoxalurias

Primary hyperoxalurias (PHs) are a group of inherited alterations of the hepatic glyoxylate metabolism. PHs classification based on gene mutations parallel a variety of enzymatic defects, and all involve the harmful accumulation of calcium oxalate crystals that produce systemic damage. These geograp...

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Bibliographic Details
Main Authors: Maria Dolores Moya-Garzon, Jose Antonio Gomez-Vidal, Alfonso Alejo-Armijo, Joaquin Altarejos, Juan Roberto Rodriguez-Madoz, Miguel Xavier Fernandes, Eduardo Salido, Sofia Salido, Monica Diaz-Gavilan
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Journal of Personalized Medicine
Subjects:
hyperoxaluria
oxalate
inhibitor
small molecule drug
glycolate oxidase
lactate dehydrogenase
Online Access:https://www.mdpi.com/2075-4426/11/2/74

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