The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights
A number of clinical studies have reported that diabetes mellitus (DM) is an independent risk factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age, sex, and cardiovascular risk factors, DM remains a significant if modest risk factor for development of AF....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00135/full |
| _version_ | 1811323341744635904 |
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| author | Loryn J. Bohne Dustin Johnson Robert A. Rose Stephen B. Wilton Anne M. Gillis |
| author_facet | Loryn J. Bohne Dustin Johnson Robert A. Rose Stephen B. Wilton Anne M. Gillis |
| author_sort | Loryn J. Bohne |
| collection | DOAJ |
| description | A number of clinical studies have reported that diabetes mellitus (DM) is an independent risk factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age, sex, and cardiovascular risk factors, DM remains a significant if modest risk factor for development of AF. The mechanisms underlying the increased susceptibility to AF in DM are incompletely understood, but are thought to involve electrical, structural, and autonomic remodeling in the atria. Electrical remodeling in DM may involve alterations in gap junction function that affect atrial conduction velocity due to changes in expression or localization of connexins. Electrical remodeling can also occur due to changes in atrial action potential morphology in association with changes in ionic currents, such as sodium or potassium currents, that can affect conduction velocity or susceptibility to triggered activity. Structural remodeling in DM results in atrial fibrosis, which can alter conduction patterns and susceptibility to re-entry in the atria. In addition, increases in atrial adipose tissue, especially in Type II DM, can lead to disruptions in atrial conduction velocity or conduction patterns that may affect arrhythmogenesis. Whether the insulin resistance in type II DM activates unique intracellular signaling pathways independent of obesity requires further investigation. In addition, the relationship between incident AF and glycemic control requires further study. |
| first_indexed | 2024-04-13T13:53:36Z |
| format | Article |
| id | doaj.art-8a1a720318ed4da6819d089835122780 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-13T13:53:36Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8a1a720318ed4da6819d0898351227802022-12-22T02:44:17ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-02-011010.3389/fphys.2019.00135391958The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic InsightsLoryn J. BohneDustin JohnsonRobert A. RoseStephen B. WiltonAnne M. GillisA number of clinical studies have reported that diabetes mellitus (DM) is an independent risk factor for Atrial fibrillation (AF). After adjustment for other known risk factors including age, sex, and cardiovascular risk factors, DM remains a significant if modest risk factor for development of AF. The mechanisms underlying the increased susceptibility to AF in DM are incompletely understood, but are thought to involve electrical, structural, and autonomic remodeling in the atria. Electrical remodeling in DM may involve alterations in gap junction function that affect atrial conduction velocity due to changes in expression or localization of connexins. Electrical remodeling can also occur due to changes in atrial action potential morphology in association with changes in ionic currents, such as sodium or potassium currents, that can affect conduction velocity or susceptibility to triggered activity. Structural remodeling in DM results in atrial fibrosis, which can alter conduction patterns and susceptibility to re-entry in the atria. In addition, increases in atrial adipose tissue, especially in Type II DM, can lead to disruptions in atrial conduction velocity or conduction patterns that may affect arrhythmogenesis. Whether the insulin resistance in type II DM activates unique intracellular signaling pathways independent of obesity requires further investigation. In addition, the relationship between incident AF and glycemic control requires further study.https://www.frontiersin.org/article/10.3389/fphys.2019.00135/fullatrial fibrillationdiabetes mellitusrisk factorsmechanismsatrial remodeling |
| spellingShingle | Loryn J. Bohne Dustin Johnson Robert A. Rose Stephen B. Wilton Anne M. Gillis The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights Frontiers in Physiology atrial fibrillation diabetes mellitus risk factors mechanisms atrial remodeling |
| title | The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights |
| title_full | The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights |
| title_fullStr | The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights |
| title_full_unstemmed | The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights |
| title_short | The Association Between Diabetes Mellitus and Atrial Fibrillation: Clinical and Mechanistic Insights |
| title_sort | association between diabetes mellitus and atrial fibrillation clinical and mechanistic insights |
| topic | atrial fibrillation diabetes mellitus risk factors mechanisms atrial remodeling |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00135/full |
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