Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity
In the present study, we synthesized a Schiff base ($\mathrm{L}^{1}$) derived from L-phenylalanine with furfuraldehyde and its Pt(II) complex ([Pt($\mathrm{L}^{1}$)($\mathrm{L}^{2}$)]: [Pt(N-(furfuralidene)phenylalanine)(8-hydroxyquinoline)]) in the presence of 8-hydroxyquinoline ($\mathrm{L}^{2}$)....
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| Format: | Article |
| Language: | English |
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Académie des sciences
2020-06-01
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| Series: | Comptes Rendus. Chimie |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.9/ |
| _version_ | 1797651392268075008 |
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| author | Altun, Özlen Koçer, Melike Özge |
| author_facet | Altun, Özlen Koçer, Melike Özge |
| author_sort | Altun, Özlen |
| collection | DOAJ |
| description | In the present study, we synthesized a Schiff base ($\mathrm{L}^{1}$) derived from L-phenylalanine with furfuraldehyde and its Pt(II) complex ([Pt($\mathrm{L}^{1}$)($\mathrm{L}^{2}$)]: [Pt(N-(furfuralidene)phenylalanine)(8-hydroxyquinoline)]) in the presence of 8-hydroxyquinoline ($\mathrm{L}^{2}$). The chemical structures of the synthesized Schiff base and Pt(II) complex were characterized using ESI-MS, UV–Visible, FT-IR, 1H NMR, 13C NMR, and powder-XRD spectroscopy. The surface morphologies and elemental composition were determined by SEM and EDX. Thermal analysis was performed with TG-DTA. Mole ratio of Meyer and Job methods were used for the composition of complexes. According to these methods, the ratio [$\mathrm{Pt}^{2+}$] : [$\mathrm{L}^{1} + \mathrm{L}^{2}$] was found to be 1 : 1. In addition, the antimicrobial activities of $\mathrm{L}^{1}$ and the complex showed that the compounds have significant antibacterial and antifungal properties. They also show important cytotoxic effects against the growth of mouse embryo fibroblasts (MEF) and human prostate adenocarcinoma (Du145) cancer cells. $\mathrm{L}^{1}$, $\mathrm{L}^{2}$, and the Pt(II) complex also displayed effective antioxidant activity. |
| first_indexed | 2024-03-11T16:14:19Z |
| format | Article |
| id | doaj.art-8a1b4f72bbdb443c923cb5efba6fc475 |
| institution | Directory Open Access Journal |
| issn | 1878-1543 |
| language | English |
| last_indexed | 2024-03-11T16:14:19Z |
| publishDate | 2020-06-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj.art-8a1b4f72bbdb443c923cb5efba6fc4752023-10-24T14:22:41ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432020-06-0123212714210.5802/crchim.910.5802/crchim.9Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activityAltun, Özlen0Koçer, Melike Özge1Trakya University, Department of General and Inorganic Chemistry, 22030 Edirne/TURKEYTrakya University, Department of General and Inorganic Chemistry, 22030 Edirne/TURKEYIn the present study, we synthesized a Schiff base ($\mathrm{L}^{1}$) derived from L-phenylalanine with furfuraldehyde and its Pt(II) complex ([Pt($\mathrm{L}^{1}$)($\mathrm{L}^{2}$)]: [Pt(N-(furfuralidene)phenylalanine)(8-hydroxyquinoline)]) in the presence of 8-hydroxyquinoline ($\mathrm{L}^{2}$). The chemical structures of the synthesized Schiff base and Pt(II) complex were characterized using ESI-MS, UV–Visible, FT-IR, 1H NMR, 13C NMR, and powder-XRD spectroscopy. The surface morphologies and elemental composition were determined by SEM and EDX. Thermal analysis was performed with TG-DTA. Mole ratio of Meyer and Job methods were used for the composition of complexes. According to these methods, the ratio [$\mathrm{Pt}^{2+}$] : [$\mathrm{L}^{1} + \mathrm{L}^{2}$] was found to be 1 : 1. In addition, the antimicrobial activities of $\mathrm{L}^{1}$ and the complex showed that the compounds have significant antibacterial and antifungal properties. They also show important cytotoxic effects against the growth of mouse embryo fibroblasts (MEF) and human prostate adenocarcinoma (Du145) cancer cells. $\mathrm{L}^{1}$, $\mathrm{L}^{2}$, and the Pt(II) complex also displayed effective antioxidant activity.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.9/SynthesisSpectral CharacterizationAntimicrobial ActivityCytotoxic ActivityAntioxidant Activity |
| spellingShingle | Altun, Özlen Koçer, Melike Özge Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity Comptes Rendus. Chimie Synthesis Spectral Characterization Antimicrobial Activity Cytotoxic Activity Antioxidant Activity |
| title | Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity |
| title_full | Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity |
| title_fullStr | Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity |
| title_full_unstemmed | Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity |
| title_short | Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity |
| title_sort | pt ii complex of schiff base derived from l phenylalanine and furfuraldehyde in the presence of 8 hydroxyquinoline structural analysis composition of complex and biological activity |
| topic | Synthesis Spectral Characterization Antimicrobial Activity Cytotoxic Activity Antioxidant Activity |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.9/ |
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