Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma
It is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-established in clinic...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2017-11-01
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| Series: | Radiology and Oncology |
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| Online Access: | https://doi.org/10.1515/raon-2017-0042 |
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| author | Adeberg Sebastian Bernhardt Denise Harrabi Semi B. Nicolay Nils H. Hörner-Rieber Juliane König Laila Repka Michael Mohr Angela Abdollahi Amir Weber Klaus-Josef Debus Juergen Rieken Stefan |
| author_facet | Adeberg Sebastian Bernhardt Denise Harrabi Semi B. Nicolay Nils H. Hörner-Rieber Juliane König Laila Repka Michael Mohr Angela Abdollahi Amir Weber Klaus-Josef Debus Juergen Rieken Stefan |
| author_sort | Adeberg Sebastian |
| collection | DOAJ |
| description | It is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-established in clinical use the influence of metformin in glioblastoma is far from being understood especially in combination with other treatment modalities such as radiation and temozolomide. |
| first_indexed | 2024-12-18T01:08:13Z |
| format | Article |
| id | doaj.art-8a1cfb71cb26495e844413b317a6b180 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-12-18T01:08:13Z |
| publishDate | 2017-11-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-8a1cfb71cb26495e844413b317a6b1802022-12-21T21:26:11ZengSciendoRadiology and Oncology1581-32072017-11-0151443143710.1515/raon-2017-0042raon-2017-0042Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastomaAdeberg Sebastian0Bernhardt Denise1Harrabi Semi B.2Nicolay Nils H.3Hörner-Rieber Juliane4König Laila5Repka Michael6Mohr Angela7Abdollahi Amir8Weber Klaus-Josef9Debus Juergen10Rieken Stefan11University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyDepartment of Radiation Medicine, Georgetown University Hospital, Washington DC, USAUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyIt is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-established in clinical use the influence of metformin in glioblastoma is far from being understood especially in combination with other treatment modalities such as radiation and temozolomide.https://doi.org/10.1515/raon-2017-0042metforminglycolysismetabolismgliomasproliferationcell cycle |
| spellingShingle | Adeberg Sebastian Bernhardt Denise Harrabi Semi B. Nicolay Nils H. Hörner-Rieber Juliane König Laila Repka Michael Mohr Angela Abdollahi Amir Weber Klaus-Josef Debus Juergen Rieken Stefan Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma Radiology and Oncology metformin glycolysis metabolism gliomas proliferation cell cycle |
| title | Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma |
| title_full | Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma |
| title_fullStr | Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma |
| title_full_unstemmed | Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma |
| title_short | Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma |
| title_sort | metformin enhanced in vitro radiosensitivity associates with g2 m cell cycle arrest and elevated adenosine 5 monophosphate activated protein kinase levels in glioblastoma |
| topic | metformin glycolysis metabolism gliomas proliferation cell cycle |
| url | https://doi.org/10.1515/raon-2017-0042 |
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