Precise Epigenetic Analysis Using Targeted Bisulfite Genomic Sequencing Distinguishes FSHD1, FSHD2, and Healthy Subjects

Precise Epigenetic Analysis Using Targeted Bisulfite Genomic Sequencing Distinguishes FSHD1, FSHD2, and Healthy Subjects

The true prevalence of facioscapulohumeral muscular dystrophy (FSHD) is unknown due to difficulties with accurate clinical evaluation and the complexities of current genetic diagnostics. Interestingly, all forms of FSHD are linked to epigenetic changes in the chromosome 4q35 D4Z4 macrosatellite, sug...

Full description

Bibliographic Details
Main Authors: Taylor Gould, Takako I. Jones, Peter L. Jones
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Diagnostics
Subjects:
muscular dystrophy
epigenetics
DUX4
D4Z4
FSHD
DNA methylation
Online Access:https://www.mdpi.com/2075-4418/11/8/1469

Similar Items

Similar Items