Human Skin Aging and the Anti-Aging Properties of Retinol
The skin is the most-extensive and -abundant tissue in the human body. Like many organs, as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This can be primarily attributed to the diminishing population of epidermal stem cells and the reduction in collagen, which is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/11/1614 |
| _version_ | 1827640437431599104 |
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| author | Taihao Quan |
| author_facet | Taihao Quan |
| author_sort | Taihao Quan |
| collection | DOAJ |
| description | The skin is the most-extensive and -abundant tissue in the human body. Like many organs, as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This can be primarily attributed to the diminishing population of epidermal stem cells and the reduction in collagen, which is the primary structural protein in the human body. The alterations occurring in the epidermis and dermis due to the aging process result in disruptions to the structure and functionality of the skin. This creates a microenvironment conducive to age-related skin conditions such as a compromised skin barrier, slowed wound healing, and the onset of skin cancer. This review emphasizes the recent molecular discoveries related to skin aging and evaluates preventive approaches, such as the use of topical retinoids. Topical retinoids have demonstrated promise in enhancing skin texture, diminishing fine lines, and augmenting the thickness of both the epidermal and dermal layers. |
| first_indexed | 2024-03-09T16:58:45Z |
| format | Article |
| id | doaj.art-8a1d36f821eb43dd95ca26c1d5793e19 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T16:58:45Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-8a1d36f821eb43dd95ca26c1d5793e192023-11-24T14:31:57ZengMDPI AGBiomolecules2218-273X2023-11-011311161410.3390/biom13111614Human Skin Aging and the Anti-Aging Properties of RetinolTaihao Quan0Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USAThe skin is the most-extensive and -abundant tissue in the human body. Like many organs, as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This can be primarily attributed to the diminishing population of epidermal stem cells and the reduction in collagen, which is the primary structural protein in the human body. The alterations occurring in the epidermis and dermis due to the aging process result in disruptions to the structure and functionality of the skin. This creates a microenvironment conducive to age-related skin conditions such as a compromised skin barrier, slowed wound healing, and the onset of skin cancer. This review emphasizes the recent molecular discoveries related to skin aging and evaluates preventive approaches, such as the use of topical retinoids. Topical retinoids have demonstrated promise in enhancing skin texture, diminishing fine lines, and augmenting the thickness of both the epidermal and dermal layers.https://www.mdpi.com/2218-273X/13/11/1614skin agingretinolcollagenMMPsTGF-β |
| spellingShingle | Taihao Quan Human Skin Aging and the Anti-Aging Properties of Retinol Biomolecules skin aging retinol collagen MMPs TGF-β |
| title | Human Skin Aging and the Anti-Aging Properties of Retinol |
| title_full | Human Skin Aging and the Anti-Aging Properties of Retinol |
| title_fullStr | Human Skin Aging and the Anti-Aging Properties of Retinol |
| title_full_unstemmed | Human Skin Aging and the Anti-Aging Properties of Retinol |
| title_short | Human Skin Aging and the Anti-Aging Properties of Retinol |
| title_sort | human skin aging and the anti aging properties of retinol |
| topic | skin aging retinol collagen MMPs TGF-β |
| url | https://www.mdpi.com/2218-273X/13/11/1614 |
| work_keys_str_mv | AT taihaoquan humanskinagingandtheantiagingpropertiesofretinol |