Butein inhibits corticosterone-induced apoptosis of Neuro2A cells by maintaining MEK-ERK signaling

Butein inhibits corticosterone-induced apoptosis of Neuro2A cells by maintaining MEK-ERK signaling

Stress-induced overactivation of glucocorticoid signaling may contribute to mental illness by inducing neuronal death and dysfunction. We previously reported that pretreatment with the plant flavonoid butein inhibits corticosterone (CORT)-induced apoptosis of Neuro2A (N2A) cells. In the current stud...

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Bibliographic Details
Main Authors: Masanori Ohmoto, Masaya Takemoto, Tohru Daikoku
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:IBRO Neuroscience Reports
Subjects:
Butein
Corticosterone
Apoptosis
Neuro2A cells
MEK
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242123000404

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