Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018
Background: The aim of the study was to analyze the treatment outcome and genetic characteristics of acute promyelocytic leukemia (APL) in children in Poland from 2005 to 2018.Methods: All 41 patients diagnosed with APL in Poland during the analysis period were eligible for the study. In period I (2...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00086/full |
| _version_ | 1818921700282073088 |
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| author | Małgorzata Czogała Małgorzata Czogała Katarzyna Pawińska-Wa̧sikowska Katarzyna Pawińska-Wa̧sikowska Teofila Ksia̧żek Teofila Ksia̧żek Barbara Sikorska-Fic Michał Matysiak Anna Rodziewicz-Konarska Alicja Chybicka Jolanta Skalska-Sadowska Jacek Wachowiak Katarzyna Muszyńska-Rosłan Maryna Krawczuk-Rybak Dominik Grabowski Jerzy Kowalczyk Karolina Zielezińska Tomasz Urasiński Renata Tomaszewska Tomasz Szczepański Irena Karpińska-Derda Mariola Woszczyk Joanna Pohorecka Grażyna Karolczyk Wojciech Młynarski Katarzyna Mycko Wanda Badowska Szymon Skoczeń Szymon Skoczeń Walentyna Balwierz Walentyna Balwierz |
| author_facet | Małgorzata Czogała Małgorzata Czogała Katarzyna Pawińska-Wa̧sikowska Katarzyna Pawińska-Wa̧sikowska Teofila Ksia̧żek Teofila Ksia̧żek Barbara Sikorska-Fic Michał Matysiak Anna Rodziewicz-Konarska Alicja Chybicka Jolanta Skalska-Sadowska Jacek Wachowiak Katarzyna Muszyńska-Rosłan Maryna Krawczuk-Rybak Dominik Grabowski Jerzy Kowalczyk Karolina Zielezińska Tomasz Urasiński Renata Tomaszewska Tomasz Szczepański Irena Karpińska-Derda Mariola Woszczyk Joanna Pohorecka Grażyna Karolczyk Wojciech Młynarski Katarzyna Mycko Wanda Badowska Szymon Skoczeń Szymon Skoczeń Walentyna Balwierz Walentyna Balwierz |
| author_sort | Małgorzata Czogała |
| collection | DOAJ |
| description | Background: The aim of the study was to analyze the treatment outcome and genetic characteristics of acute promyelocytic leukemia (APL) in children in Poland from 2005 to 2018.Methods: All 41 patients diagnosed with APL in Poland during the analysis period were eligible for the study. In period I (2005–2015), 33 patients were treated with chemotherapy and all-trans retinoic acid (ATRA), and in period II (2015–2018), 3 patients (high risk) received induction chemotherapy with ATRA and arsenic trioxide (ATO), and 5 patients (standard risk) received ATRA and ATO without chemotherapy.Results: Probability of 5-years overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) was 0.819 ± 0.069, 0.831 ± 0.063, and 0.961 ± 0.037, respectively, in the whole cohort. Four (11%) early deaths were observed. One patient died of severe infection in the course of disease progression. Relapse occurred in one patient, who died finally because of disease progression. All events occurred in the patients from period I. Variant APL was identified in one patient (successfully treated with chemotherapy with ATRA) and complex translocation in one patient (the only patient with relapse). Additional chromosomal aberrations were found in 26% of patients and FLT3-ITD mutation was detected in 44% of patients; none of those changes influenced clinical outcome.Conclusion: Treatment outcome in the analyzed group is similar to the results reported by other study groups. The main cause of death was coagulation disorders in the early stage of disease. Early, accurate diagnosis followed by specific treatment enables the reduction in the number of early deaths. |
| first_indexed | 2024-12-20T01:41:49Z |
| format | Article |
| id | doaj.art-8a1e7cab6ea047aebc3656a819a8cc53 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-20T01:41:49Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-8a1e7cab6ea047aebc3656a819a8cc532022-12-21T19:57:52ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-03-01810.3389/fped.2020.00086511284Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018Małgorzata Czogała0Małgorzata Czogała1Katarzyna Pawińska-Wa̧sikowska2Katarzyna Pawińska-Wa̧sikowska3Teofila Ksia̧żek4Teofila Ksia̧żek5Barbara Sikorska-Fic6Michał Matysiak7Anna Rodziewicz-Konarska8Alicja Chybicka9Jolanta Skalska-Sadowska10Jacek Wachowiak11Katarzyna Muszyńska-Rosłan12Maryna Krawczuk-Rybak13Dominik Grabowski14Jerzy Kowalczyk15Karolina Zielezińska16Tomasz Urasiński17Renata Tomaszewska18Tomasz Szczepański19Irena Karpińska-Derda20Mariola Woszczyk21Joanna Pohorecka22Grażyna Karolczyk23Wojciech Młynarski24Katarzyna Mycko25Wanda Badowska26Szymon Skoczeń27Szymon Skoczeń28Walentyna Balwierz29Walentyna Balwierz30Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, PolandDepartment of Pediatric Oncology and Hematology, University Children Hospital, Krakow, PolandDepartment of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, PolandDepartment of Pediatric Oncology and Hematology, University Children Hospital, Krakow, PolandDepartment of Pediatric Oncology and Hematology, University Children Hospital, Krakow, PolandDepartment of Medical Genetics, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, PolandDepartment of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, PolandDepartment of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Warsaw, PolandDepartment of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Medical University of Wroclaw, Wroclaw, PolandDepartment of Bone Marrow Transplantation, Pediatric Oncology and Hematology, Medical University of Wroclaw, Wroclaw, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, Poznan, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, PolandDepartment of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, PolandDepartment of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, PolandDepartment of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, PolandDepartment of Pediatrics, Hematology and Oncology, Pomeranian Medical University, Szczecin, PolandDepartment of Pediatrics, Hematology and Oncology, Pomeranian Medical University, Szczecin, Poland0Department of Pediatrics Hematology and Oncology, Medical University of Silesia, Zabrze, Poland0Department of Pediatrics Hematology and Oncology, Medical University of Silesia, Zabrze, Poland1Department of Pediatrics, Hematology and Oncology, City Hospital, Chorzów, Poland1Department of Pediatrics, Hematology and Oncology, City Hospital, Chorzów, Poland2Paediatric Department of Hematology and Oncology, Regional Polyclinic Hospital in Kielce, Kielce, Poland2Paediatric Department of Hematology and Oncology, Regional Polyclinic Hospital in Kielce, Kielce, Poland3Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Lodz, Poland4Department of Pediatrics and Hematology and Oncology, Province Children's Hospital, Olsztyn, Poland4Department of Pediatrics and Hematology and Oncology, Province Children's Hospital, Olsztyn, PolandDepartment of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, PolandDepartment of Pediatric Oncology and Hematology, University Children Hospital, Krakow, PolandDepartment of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, Krakow, PolandDepartment of Pediatric Oncology and Hematology, University Children Hospital, Krakow, PolandBackground: The aim of the study was to analyze the treatment outcome and genetic characteristics of acute promyelocytic leukemia (APL) in children in Poland from 2005 to 2018.Methods: All 41 patients diagnosed with APL in Poland during the analysis period were eligible for the study. In period I (2005–2015), 33 patients were treated with chemotherapy and all-trans retinoic acid (ATRA), and in period II (2015–2018), 3 patients (high risk) received induction chemotherapy with ATRA and arsenic trioxide (ATO), and 5 patients (standard risk) received ATRA and ATO without chemotherapy.Results: Probability of 5-years overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) was 0.819 ± 0.069, 0.831 ± 0.063, and 0.961 ± 0.037, respectively, in the whole cohort. Four (11%) early deaths were observed. One patient died of severe infection in the course of disease progression. Relapse occurred in one patient, who died finally because of disease progression. All events occurred in the patients from period I. Variant APL was identified in one patient (successfully treated with chemotherapy with ATRA) and complex translocation in one patient (the only patient with relapse). Additional chromosomal aberrations were found in 26% of patients and FLT3-ITD mutation was detected in 44% of patients; none of those changes influenced clinical outcome.Conclusion: Treatment outcome in the analyzed group is similar to the results reported by other study groups. The main cause of death was coagulation disorders in the early stage of disease. Early, accurate diagnosis followed by specific treatment enables the reduction in the number of early deaths.https://www.frontiersin.org/article/10.3389/fped.2020.00086/fullacute promyelocytic leukemiachildrenvariant translocationstreatment resultsATOATRA |
| spellingShingle | Małgorzata Czogała Małgorzata Czogała Katarzyna Pawińska-Wa̧sikowska Katarzyna Pawińska-Wa̧sikowska Teofila Ksia̧żek Teofila Ksia̧żek Barbara Sikorska-Fic Michał Matysiak Anna Rodziewicz-Konarska Alicja Chybicka Jolanta Skalska-Sadowska Jacek Wachowiak Katarzyna Muszyńska-Rosłan Maryna Krawczuk-Rybak Dominik Grabowski Jerzy Kowalczyk Karolina Zielezińska Tomasz Urasiński Renata Tomaszewska Tomasz Szczepański Irena Karpińska-Derda Mariola Woszczyk Joanna Pohorecka Grażyna Karolczyk Wojciech Młynarski Katarzyna Mycko Wanda Badowska Szymon Skoczeń Szymon Skoczeń Walentyna Balwierz Walentyna Balwierz Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018 Frontiers in Pediatrics acute promyelocytic leukemia children variant translocations treatment results ATO ATRA |
| title | Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018 |
| title_full | Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018 |
| title_fullStr | Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018 |
| title_full_unstemmed | Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018 |
| title_short | Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018 |
| title_sort | treatment outcome and the genetic characteristics of acute promyelocytic leukemia in children in poland from 2005 to 2018 |
| topic | acute promyelocytic leukemia children variant translocations treatment results ATO ATRA |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00086/full |
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