Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in Rats
Background & Objective: Alcohol overdose can induce increment in free radicals. The present study aimed to investigate the effect of swimming training and Curcumin in withdrawal period of alcohol overdose on superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (T...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2018-12-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1555-en.pdf |
| _version_ | 1797679636907294720 |
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| author | Asiye Seyed Sirous Farsi Seyed Ali Hosseini Gholamreza Kaka |
| author_facet | Asiye Seyed Sirous Farsi Seyed Ali Hosseini Gholamreza Kaka |
| author_sort | Asiye Seyed |
| collection | DOAJ |
| description | Background & Objective: Alcohol overdose can induce increment in free radicals. The present study aimed to investigate the effect of swimming training and Curcumin in withdrawal period of alcohol overdose on superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), malone dealdeid (MDA) and protein carbonyl (PC) of rats.
Materials & Methods: 40 rats were selected and administered alcohol every 8 hours for 4 days. Then they were subjected to the withdrawal of alcohol for six days and in seventh day divided in 5 groups of 8 rats (1) control (2) Curcumin (3) swimming training (4) Curcumin and swimming training (5) sham. Groups 3 and 4 swam 5 sessions per week for 2 weeks and groups 2 and 4 used Curcumin 5 times per week for 2 weeks peritoneally. For statistical analysis of data two-way ANOVA was used (p≤0.05).
Results: Swimming training had significant effect on increase of SOD (p=0.001), GPX (p=0.001) and TAC (p=0.009) and reduction of MDA (p=0.001) and PC (p=0.001) of rats. Curcumin had significant effect on increase of SOD (p=0.001) and GPX (p=0.001) and reduction of MDA (p=0.001) and PC (p=0.001) of rats but had no significant effect on TAC (p=0.34) also Curcumin and swimming training had interactive effects on increase of SOD (p=0.001) and GPX (p=0.001) and reduction of PC (p=0.009) of rats but had no interactional effect on TAC (p=0.48) and MDA (p=0.13).
Conclusion: Probably, swimming training and curcumin can be applied simultaneously in withdrawal period of alcohol overdose to increase antioxidant factors. |
| first_indexed | 2024-03-11T23:17:41Z |
| format | Article |
| id | doaj.art-8a1f2e2d6de544ef89894faf4112e4bb |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:41Z |
| publishDate | 2018-12-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-8a1f2e2d6de544ef89894faf4112e4bb2023-09-20T21:24:38ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232018-12-0183901910Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in RatsAsiye Seyed0Sirous Farsi1Seyed Ali Hosseini2Gholamreza Kaka3 Islamic Azad University, Larestan, Iran Islamic Azad University, Larestan, Iran Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Bagiyatallah University of Medical Sciences, Tehran, Iran Background & Objective: Alcohol overdose can induce increment in free radicals. The present study aimed to investigate the effect of swimming training and Curcumin in withdrawal period of alcohol overdose on superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), malone dealdeid (MDA) and protein carbonyl (PC) of rats. Materials & Methods: 40 rats were selected and administered alcohol every 8 hours for 4 days. Then they were subjected to the withdrawal of alcohol for six days and in seventh day divided in 5 groups of 8 rats (1) control (2) Curcumin (3) swimming training (4) Curcumin and swimming training (5) sham. Groups 3 and 4 swam 5 sessions per week for 2 weeks and groups 2 and 4 used Curcumin 5 times per week for 2 weeks peritoneally. For statistical analysis of data two-way ANOVA was used (p≤0.05). Results: Swimming training had significant effect on increase of SOD (p=0.001), GPX (p=0.001) and TAC (p=0.009) and reduction of MDA (p=0.001) and PC (p=0.001) of rats. Curcumin had significant effect on increase of SOD (p=0.001) and GPX (p=0.001) and reduction of MDA (p=0.001) and PC (p=0.001) of rats but had no significant effect on TAC (p=0.34) also Curcumin and swimming training had interactive effects on increase of SOD (p=0.001) and GPX (p=0.001) and reduction of PC (p=0.009) of rats but had no interactional effect on TAC (p=0.48) and MDA (p=0.13). Conclusion: Probably, swimming training and curcumin can be applied simultaneously in withdrawal period of alcohol overdose to increase antioxidant factors.http://jabs.fums.ac.ir/article-1-1555-en.pdfswimming trainingcurcuminantioxidantalcohol |
| spellingShingle | Asiye Seyed Sirous Farsi Seyed Ali Hosseini Gholamreza Kaka Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in Rats Journal of Advanced Biomedical Sciences swimming training curcumin antioxidant alcohol |
| title | Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in Rats |
| title_full | Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in Rats |
| title_fullStr | Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in Rats |
| title_full_unstemmed | Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in Rats |
| title_short | Antioxidant Effects of Swimming Training and Curcumin in Withdrawal Period of Alcohol Overdose in Rats |
| title_sort | antioxidant effects of swimming training and curcumin in withdrawal period of alcohol overdose in rats |
| topic | swimming training curcumin antioxidant alcohol |
| url | http://jabs.fums.ac.ir/article-1-1555-en.pdf |
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