Facilitation of Gastrointestinal (GI) Tract Microbiome-Derived Lipopolysaccharide (LPS) Entry Into Human Neurons by Amyloid Beta-42 (Aβ42) Peptide

Facilitation of Gastrointestinal (GI) Tract Microbiome-Derived Lipopolysaccharide (LPS) Entry Into Human Neurons by Amyloid Beta-42 (Aβ42) Peptide

Human gastrointestinal (GI)-tract microbiome-derived lipopolysaccharide (LPS): (i) has been recently shown to target, accumulate within, and eventually encapsulate neuronal nuclei of the human central nervous system (CNS) in Alzheimer’s disease (AD) brain; and (ii) this action appears to impede and...

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Bibliographic Details
Main Authors: Walter J. Lukiw, Wenhong Li, Taylor Bond, Yuhai Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease (AD)
brain microbiome
dysbiosis
gastrointestinal (GI) tract
lipopolysaccharide (LPS)
neurofilament light (NF-L)
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00545/full

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