Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study
Abstract Background and aims Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-05-01
|
| Series: | Nutrition Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12937-022-00786-w |
| _version_ | 1818211394880798720 |
|---|---|
| author | Yu Cheng Shuai Liu Duo Chen Yiman Yang Qiongyue Liang Ya Huo Ziyi Zhou Nan Zhang Zhuo Wang Lishun Liu Yun Song Xiangyi Liu Yong Duan Xiuwen Liang Bingjie Hou Binyan Wang Genfu Tang Xianhui Qin Fangrong Yan |
| author_facet | Yu Cheng Shuai Liu Duo Chen Yiman Yang Qiongyue Liang Ya Huo Ziyi Zhou Nan Zhang Zhuo Wang Lishun Liu Yun Song Xiangyi Liu Yong Duan Xiuwen Liang Bingjie Hou Binyan Wang Genfu Tang Xianhui Qin Fangrong Yan |
| author_sort | Yu Cheng |
| collection | DOAJ |
| description | Abstract Background and aims Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. Methods Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. Results There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: β = − 0.50, P < 0.001; CC: β = − 0.14, P = 0.087; CT: β = − 0.20, P = 0.011; TT: β = − 1.19, P < 0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference < 0.001) and genotype CT participants (P for difference < 0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). Conclusions Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T. |
| first_indexed | 2024-12-12T05:31:49Z |
| format | Article |
| id | doaj.art-8a22f0da6a304442b0491a4b216684bc |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-12-12T05:31:49Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-8a22f0da6a304442b0491a4b216684bc2022-12-22T00:36:17ZengBMCNutrition Journal1475-28912022-05-012111910.1186/s12937-022-00786-wAssociation between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional studyYu Cheng0Shuai Liu1Duo Chen2Yiman Yang3Qiongyue Liang4Ya Huo5Ziyi Zhou6Nan Zhang7Zhuo Wang8Lishun Liu9Yun Song10Xiangyi Liu11Yong Duan12Xiuwen Liang13Bingjie Hou14Binyan Wang15Genfu Tang16Xianhui Qin17Fangrong Yan18State Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityDepartment of Cardiology, Peking University First HospitalBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural UniversityBeiJing TongRen Hospital, CMUYunnan Key Laboratory of Laboratory MedicineChina Mongolia Hospital of HulunbuirThe Fourth Central Hospital of Baoding CityInstitute of Biomedicine, Anhui Medical UniversitySchool of Health Administration, Anhui Medical UniversityDivision of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong LaboratoryState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical UniversityAbstract Background and aims Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. Methods Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. Results There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: β = − 0.50, P < 0.001; CC: β = − 0.14, P = 0.087; CT: β = − 0.20, P = 0.011; TT: β = − 1.19, P < 0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference < 0.001) and genotype CT participants (P for difference < 0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). Conclusions Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was ≤ 10 ng/mL, and this association was modified by MTHFR C677T.https://doi.org/10.1186/s12937-022-00786-w5-methyltetrahydrofolateHomocysteineMTHFR C677T |
| spellingShingle | Yu Cheng Shuai Liu Duo Chen Yiman Yang Qiongyue Liang Ya Huo Ziyi Zhou Nan Zhang Zhuo Wang Lishun Liu Yun Song Xiangyi Liu Yong Duan Xiuwen Liang Bingjie Hou Binyan Wang Genfu Tang Xianhui Qin Fangrong Yan Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study Nutrition Journal 5-methyltetrahydrofolate Homocysteine MTHFR C677T |
| title | Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study |
| title_full | Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study |
| title_fullStr | Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study |
| title_full_unstemmed | Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study |
| title_short | Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study |
| title_sort | association between serum 5 methyltetrahydrofolate and homocysteine in chinese hypertensive participants with different mthfr c677t polymorphisms a cross sectional study |
| topic | 5-methyltetrahydrofolate Homocysteine MTHFR C677T |
| url | https://doi.org/10.1186/s12937-022-00786-w |
| work_keys_str_mv | AT yucheng associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT shuailiu associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT duochen associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT yimanyang associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT qiongyueliang associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT yahuo associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT ziyizhou associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT nanzhang associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT zhuowang associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT lishunliu associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT yunsong associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT xiangyiliu associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT yongduan associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT xiuwenliang associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT bingjiehou associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT binyanwang associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT genfutang associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT xianhuiqin associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy AT fangrongyan associationbetweenserum5methyltetrahydrofolateandhomocysteineinchinesehypertensiveparticipantswithdifferentmthfrc677tpolymorphismsacrosssectionalstudy |