Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma
Background and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related...
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| Format: | Article |
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Iranian Society of Pathology
2019-04-01
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| Series: | Iranian Journal of Pathology |
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| Online Access: | https://ijp.iranpath.org/article_35536_ccbba5d6642fb9e9331fa1eba71d5d77.pdf |
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| author | Amir Hossein Jafarian Nema Mohammadian Roshan Masoumeh Gharib Vahid Moshirahmadi Aida Tasbandi Amir Ali Ayatollahi Hossein Ayatollahi |
| author_facet | Amir Hossein Jafarian Nema Mohammadian Roshan Masoumeh Gharib Vahid Moshirahmadi Aida Tasbandi Amir Ali Ayatollahi Hossein Ayatollahi |
| author_sort | Amir Hossein Jafarian |
| collection | DOAJ |
| description | Background and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related stained slides were reviewed by two pathologists. The results were interpreted according to the COX2 staining index (SI), tumor thickness (Breslow, Clark), number of mitoses per 10 hpf, and melanoma types. Gender, lymph node involvement, metastasis, and survival were considered as evaluation factors as well. Results: The expression of the COX-2 protein was evident in 98.4% of cases. A strong Staining Index(SI) was reported in 60% of all melanomas, moderate staining was detected in 20.8% and weak staining in 10%; 1.6% of studied cases showed no staining. Benign nevus specimens showed no staining for the COX-2 enzyme. Conclusion: We have demonstrated that COX-2 is strongly expressed in the majority of malignant melanomas and that the SI score of COX-2 is related to the number of mitoses, tumor thickness (based on Clark level and Breslow), melanoma sub-type, lymph node involvement, and metastases; No association was noted between the anatomic site, gender, and survival. COX-2 can be applied as a prognostic factor in malignant melanoma and a promising candidate for future target therapies. |
| first_indexed | 2024-12-21T23:42:53Z |
| format | Article |
| id | doaj.art-8a236989aa644e4db3c1220e44661d4f |
| institution | Directory Open Access Journal |
| issn | 1735-5303 2345-3656 |
| language | English |
| last_indexed | 2024-12-21T23:42:53Z |
| publishDate | 2019-04-01 |
| publisher | Iranian Society of Pathology |
| record_format | Article |
| series | Iranian Journal of Pathology |
| spelling | doaj.art-8a236989aa644e4db3c1220e44661d4f2022-12-21T18:46:12ZengIranian Society of PathologyIranian Journal of Pathology1735-53032345-36562019-04-011429610310.30699/ijp.14.2.9635536Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant MelanomaAmir Hossein Jafarian0Nema Mohammadian Roshan1Masoumeh Gharib2Vahid Moshirahmadi3Aida Tasbandi4Amir Ali Ayatollahi5Hossein Ayatollahi6Associate Professor of Pathology, Department Of Pathology, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAssociate Professor of Pathology, Department Of Pathology, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAssistant Professor of Pathology, Department Of Pathology, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranCancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranAssociate Professor of Pathology, Department Of Pathology, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranBackground and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related stained slides were reviewed by two pathologists. The results were interpreted according to the COX2 staining index (SI), tumor thickness (Breslow, Clark), number of mitoses per 10 hpf, and melanoma types. Gender, lymph node involvement, metastasis, and survival were considered as evaluation factors as well. Results: The expression of the COX-2 protein was evident in 98.4% of cases. A strong Staining Index(SI) was reported in 60% of all melanomas, moderate staining was detected in 20.8% and weak staining in 10%; 1.6% of studied cases showed no staining. Benign nevus specimens showed no staining for the COX-2 enzyme. Conclusion: We have demonstrated that COX-2 is strongly expressed in the majority of malignant melanomas and that the SI score of COX-2 is related to the number of mitoses, tumor thickness (based on Clark level and Breslow), melanoma sub-type, lymph node involvement, and metastases; No association was noted between the anatomic site, gender, and survival. COX-2 can be applied as a prognostic factor in malignant melanoma and a promising candidate for future target therapies.https://ijp.iranpath.org/article_35536_ccbba5d6642fb9e9331fa1eba71d5d77.pdfmalignant melanomacox-2prognostic factors |
| spellingShingle | Amir Hossein Jafarian Nema Mohammadian Roshan Masoumeh Gharib Vahid Moshirahmadi Aida Tasbandi Amir Ali Ayatollahi Hossein Ayatollahi Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma Iranian Journal of Pathology malignant melanoma cox-2 prognostic factors |
| title | Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma |
| title_full | Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma |
| title_fullStr | Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma |
| title_full_unstemmed | Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma |
| title_short | Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma |
| title_sort | evaluation of cyclooxygenase 2 expression in association with clinical pathological factors in malignant melanoma |
| topic | malignant melanoma cox-2 prognostic factors |
| url | https://ijp.iranpath.org/article_35536_ccbba5d6642fb9e9331fa1eba71d5d77.pdf |
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