Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life
BackgroundStudies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.PurposeThe study i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.774433/full |
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| author | Hanqi Lu Yanting You Xinghong Zhou Qiuxing He Ming Wang Liqian Chen Lin Zhou Xiaomin Sun Yanyan Liu Pingping Jiang Jiaojiao Dai Xiuqiong Fu Hiu Yee Kwan Xiaoshan Zhao Xiaoshan Zhao Linjie Lou |
| author_facet | Hanqi Lu Yanting You Xinghong Zhou Qiuxing He Ming Wang Liqian Chen Lin Zhou Xiaomin Sun Yanyan Liu Pingping Jiang Jiaojiao Dai Xiuqiong Fu Hiu Yee Kwan Xiaoshan Zhao Xiaoshan Zhao Linjie Lou |
| author_sort | Hanqi Lu |
| collection | DOAJ |
| description | BackgroundStudies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.PurposeThe study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder via regulation of gut microbiome in mice exposed to antibodies early in life were investigated.Methods and ResultsThree-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. The results showed that early-life AZT exposure promoted HFD-induced glycolipid metabolism disorder, increased the levels of inflammatory factors, promoted the flora metabolism product trimethylamine N-oxide (TMAO), and induced microbial disorder in adult mice. Importantly, CRP extract mitigated these effects.ConclusionTaken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome. |
| first_indexed | 2024-12-15T00:40:49Z |
| format | Article |
| id | doaj.art-8a2587e5bdae470fa9404c984598004d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-15T00:40:49Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8a2587e5bdae470fa9404c984598004d2022-12-21T22:41:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.774433774433Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early LifeHanqi Lu0Yanting You1Xinghong Zhou2Qiuxing He3Ming Wang4Liqian Chen5Lin Zhou6Xiaomin Sun7Yanyan Liu8Pingping Jiang9Jiaojiao Dai10Xiuqiong Fu11Hiu Yee Kwan12Xiaoshan Zhao13Xiaoshan Zhao14Linjie Lou15Department of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaSchool of Chinese Medicine, Southern Medical University, Guangzhou, ChinaEndocrinology Department, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaSchool of Chinese Medicine, Southern Medical University, Guangzhou, ChinaSchool of Chinese Medicine, Southern Medical University, Guangzhou, ChinaSchool of Chinese Medicine, Southern Medical University, Guangzhou, ChinaSchool of Chinese Medicine, Southern Medical University, Guangzhou, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, ChinaSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, ChinaDepartment of Traditional Chinese Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaSchool of Chinese Medicine, Southern Medical University, Guangzhou, ChinaThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundStudies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.PurposeThe study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder via regulation of gut microbiome in mice exposed to antibodies early in life were investigated.Methods and ResultsThree-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. The results showed that early-life AZT exposure promoted HFD-induced glycolipid metabolism disorder, increased the levels of inflammatory factors, promoted the flora metabolism product trimethylamine N-oxide (TMAO), and induced microbial disorder in adult mice. Importantly, CRP extract mitigated these effects.ConclusionTaken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome.https://www.frontiersin.org/articles/10.3389/fimmu.2021.774433/fullCitrus reticulata pericarpium extractearly lifeantibiotic exposureglycolipid metabolism disorderTMAO |
| spellingShingle | Hanqi Lu Yanting You Xinghong Zhou Qiuxing He Ming Wang Liqian Chen Lin Zhou Xiaomin Sun Yanyan Liu Pingping Jiang Jiaojiao Dai Xiuqiong Fu Hiu Yee Kwan Xiaoshan Zhao Xiaoshan Zhao Linjie Lou Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life Frontiers in Immunology Citrus reticulata pericarpium extract early life antibiotic exposure glycolipid metabolism disorder TMAO |
| title | Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_full | Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_fullStr | Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_full_unstemmed | Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_short | Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_sort | citrus reticulatae pericarpium extract decreases the susceptibility to hfd induced glycolipid metabolism disorder in mice exposed to azithromycin in early life |
| topic | Citrus reticulata pericarpium extract early life antibiotic exposure glycolipid metabolism disorder TMAO |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.774433/full |
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