Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literature
Carbon monoxide (CO) poisoning during pregnancy is a rare occurrence, associated with high maternal and fetal mortality rates. As CO can cross the placenta, leading to intrauterine hypoxia, CO intoxication can result in neurological sequelae and neurologic complications in fetuses who survive. We re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1264855/full |
| _version_ | 1827773412900077568 |
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| author | Cristina Tuoni Giulia Nuzzi Giulia Nuzzi Rosa Teresa Scaramuzzo Simona Fiori Simona Fiori Luca Filippi |
| author_facet | Cristina Tuoni Giulia Nuzzi Giulia Nuzzi Rosa Teresa Scaramuzzo Simona Fiori Simona Fiori Luca Filippi |
| author_sort | Cristina Tuoni |
| collection | DOAJ |
| description | Carbon monoxide (CO) poisoning during pregnancy is a rare occurrence, associated with high maternal and fetal mortality rates. As CO can cross the placenta, leading to intrauterine hypoxia, CO intoxication can result in neurological sequelae and neurologic complications in fetuses who survive. We report a case of a preterm newborn acutely exposed to CO in-utero and delivered by emergent cesarean section at the 31st week of gestation due to the severe burns suffered by the mother following an indoor boiler explosion. As CO has serious adverse effects both on the mother and fetus, it is important to recognize and treat poisoning in a timely manner. Despite maternal blood CO levels, CO intoxication at critical stage of central nervous system development can lead to hypoxic-ischemic lesions, thus interdisciplinary care and follow up for these patients are mandatory. |
| first_indexed | 2024-03-11T13:22:34Z |
| format | Article |
| id | doaj.art-8a26b4ad28a6495f85bf3e776ff355e1 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T13:22:34Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-8a26b4ad28a6495f85bf3e776ff355e12023-11-03T10:27:33ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-11-011110.3389/fped.2023.12648551264855Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literatureCristina Tuoni0Giulia Nuzzi1Giulia Nuzzi2Rosa Teresa Scaramuzzo3Simona Fiori4Simona Fiori5Luca Filippi6Neonatology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, ItalyNeonatology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, ItalyDepartment of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, ItalyNeonatology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, ItalyDivision of Neonatology and NICU, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyCarbon monoxide (CO) poisoning during pregnancy is a rare occurrence, associated with high maternal and fetal mortality rates. As CO can cross the placenta, leading to intrauterine hypoxia, CO intoxication can result in neurological sequelae and neurologic complications in fetuses who survive. We report a case of a preterm newborn acutely exposed to CO in-utero and delivered by emergent cesarean section at the 31st week of gestation due to the severe burns suffered by the mother following an indoor boiler explosion. As CO has serious adverse effects both on the mother and fetus, it is important to recognize and treat poisoning in a timely manner. Despite maternal blood CO levels, CO intoxication at critical stage of central nervous system development can lead to hypoxic-ischemic lesions, thus interdisciplinary care and follow up for these patients are mandatory.https://www.frontiersin.org/articles/10.3389/fped.2023.1264855/fullcarbon monoxide intoxicationhypoxic-ischemic encephalopathyfetal brain damagecarboxyhemoglobincerebral palsy |
| spellingShingle | Cristina Tuoni Giulia Nuzzi Giulia Nuzzi Rosa Teresa Scaramuzzo Simona Fiori Simona Fiori Luca Filippi Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literature Frontiers in Pediatrics carbon monoxide intoxication hypoxic-ischemic encephalopathy fetal brain damage carboxyhemoglobin cerebral palsy |
| title | Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literature |
| title_full | Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literature |
| title_fullStr | Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literature |
| title_full_unstemmed | Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literature |
| title_short | Neonatal hypoxic-ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy. A case report and brief review of the literature |
| title_sort | neonatal hypoxic ischemic encephalopathy after acute carbon monoxide intoxication during pregnancy a case report and brief review of the literature |
| topic | carbon monoxide intoxication hypoxic-ischemic encephalopathy fetal brain damage carboxyhemoglobin cerebral palsy |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1264855/full |
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