Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis
Inflammatory bowel diseases (IBDs) are chronic, heterogeneous, and inflammatory conditions mainly affecting the gastrointestinal tract. Currently, endoscopy is the gold standard test for assessing mucosal activity and healing in clinical practice; however, it is a costly, time-consuming, invasive, a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10159 |
| _version_ | 1797594285638418432 |
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| author | Montse Baldan-Martin María Chaparro Javier P. Gisbert |
| author_facet | Montse Baldan-Martin María Chaparro Javier P. Gisbert |
| author_sort | Montse Baldan-Martin |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBDs) are chronic, heterogeneous, and inflammatory conditions mainly affecting the gastrointestinal tract. Currently, endoscopy is the gold standard test for assessing mucosal activity and healing in clinical practice; however, it is a costly, time-consuming, invasive, and uncomfortable procedure for the patients. Therefore, there is an urgent need for sensitive, specific, fast and non-invasive biomarkers for the diagnosis of IBD in medical research. Urine is an excellent biofluid for discovering biomarkers because it is non-invasive to sample. In this review, we aimed to summarize proteomics and metabolomics studies performed in both animal models of IBD and humans that identify urinary biomarkers for IBD diagnosis. Future large-scale multi-omics studies should be conducted in collaboration with clinicians, researchers, and industry to make progress toward the development of sensitive and specific diagnostic biomarkers, thereby making personalized medicine possible. |
| first_indexed | 2024-03-11T02:21:30Z |
| format | Article |
| id | doaj.art-8a26f882d57e4cbb9a9c76b4589259a5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:30Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8a26f882d57e4cbb9a9c76b4589259a52023-11-18T10:49:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121015910.3390/ijms241210159Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease DiagnosisMontse Baldan-Martin0María Chaparro1Javier P. Gisbert2Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28006 Madrid, SpainGastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28006 Madrid, SpainGastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28006 Madrid, SpainInflammatory bowel diseases (IBDs) are chronic, heterogeneous, and inflammatory conditions mainly affecting the gastrointestinal tract. Currently, endoscopy is the gold standard test for assessing mucosal activity and healing in clinical practice; however, it is a costly, time-consuming, invasive, and uncomfortable procedure for the patients. Therefore, there is an urgent need for sensitive, specific, fast and non-invasive biomarkers for the diagnosis of IBD in medical research. Urine is an excellent biofluid for discovering biomarkers because it is non-invasive to sample. In this review, we aimed to summarize proteomics and metabolomics studies performed in both animal models of IBD and humans that identify urinary biomarkers for IBD diagnosis. Future large-scale multi-omics studies should be conducted in collaboration with clinicians, researchers, and industry to make progress toward the development of sensitive and specific diagnostic biomarkers, thereby making personalized medicine possible.https://www.mdpi.com/1422-0067/24/12/10159inflammatory bowel diseaseCrohn’s diseaseulcerative colitisbiomarkersurineproteomics |
| spellingShingle | Montse Baldan-Martin María Chaparro Javier P. Gisbert Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis International Journal of Molecular Sciences inflammatory bowel disease Crohn’s disease ulcerative colitis biomarkers urine proteomics |
| title | Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis |
| title_full | Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis |
| title_fullStr | Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis |
| title_full_unstemmed | Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis |
| title_short | Systematic Review: Urine Biomarker Discovery for Inflammatory Bowel Disease Diagnosis |
| title_sort | systematic review urine biomarker discovery for inflammatory bowel disease diagnosis |
| topic | inflammatory bowel disease Crohn’s disease ulcerative colitis biomarkers urine proteomics |
| url | https://www.mdpi.com/1422-0067/24/12/10159 |
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