Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis
Purpose: Brain dysfunction related to areas regarding attention and arousal may occur not only in patients with attention-deficit/hyperactivity disorder (ADHD) but also in patients with enuresis and daytime symptoms. This study aimed to investigate changes in computerized comprehensive attention tes...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2020-03-01
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| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-207.pdf |
| _version_ | 1811318074256654336 |
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| author | Gwan Jang Young Jae Im Jungyo Suh Kwanjin Park |
| author_facet | Gwan Jang Young Jae Im Jungyo Suh Kwanjin Park |
| author_sort | Gwan Jang |
| collection | DOAJ |
| description | Purpose: Brain dysfunction related to areas regarding attention and arousal may occur not only in patients with attention-deficit/hyperactivity disorder (ADHD) but also in patients with enuresis and daytime symptoms. This study aimed to investigate changes in computerized comprehensive attention tests (CATs), a psychometric test for ADHD when patients with nonmonosymptomatic enuresis (NME) were treated with anticholinergic agents. Materials and Methods: Thirty patients with NME featuring overactive bladder were prospectively enrolled. They were treated with 5 mg of solifenacin to control daytime symptoms. Using CATs, patients were evaluated during 12 weeks of treatment. Four subtests of attention (visual and auditory selective attention, sustained attention, and flanker tests) were measured. For each subtest, four domains (omission error, commission error, response time [RT], and standard deviation of RT) were assessed. Results: Only one domain of the flanker test was in the deficient range at baseline. The presence of urge incontinence affected follow-up results on the sustained attention tests. Treatment with anticholinergic agents did not significantly affect attention variables but changes in several variables were correlated with bladder symptoms and enuresis. Conclusions: Minimal baseline defects in attention function were seen in patients with NME. Follow-up results for some attention variables were affected by daytime symptoms and enuresis. These results suggest that altered brain function in enuretic patients influences improvement in both attention and bladder function. |
| first_indexed | 2024-04-13T12:19:24Z |
| format | Article |
| id | doaj.art-8a288d39787548809b3e086dbf1a4f77 |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-04-13T12:19:24Z |
| publishDate | 2020-03-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-8a288d39787548809b3e086dbf1a4f772022-12-22T02:47:16ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2020-03-0161220721510.4111/icu.2020.61.2.207Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresisGwan Jang https://orcid.org/0000-0002-7278-9501Young Jae Im 0https://orcid.org/0000-0002-8285-483XJungyo Suh 1https://orcid.org/0000-0002-3867-4778Kwanjin Park 2https://orcid.org/0000-0002-8926-3047Department of Urology, Seoul National University College of Medicine, Seoul, Korea.Department of Urology, Seoul National University College of Medicine, Seoul, Korea.Department of Urology, Seoul National University College of Medicine, Seoul, Korea.Purpose: Brain dysfunction related to areas regarding attention and arousal may occur not only in patients with attention-deficit/hyperactivity disorder (ADHD) but also in patients with enuresis and daytime symptoms. This study aimed to investigate changes in computerized comprehensive attention tests (CATs), a psychometric test for ADHD when patients with nonmonosymptomatic enuresis (NME) were treated with anticholinergic agents. Materials and Methods: Thirty patients with NME featuring overactive bladder were prospectively enrolled. They were treated with 5 mg of solifenacin to control daytime symptoms. Using CATs, patients were evaluated during 12 weeks of treatment. Four subtests of attention (visual and auditory selective attention, sustained attention, and flanker tests) were measured. For each subtest, four domains (omission error, commission error, response time [RT], and standard deviation of RT) were assessed. Results: Only one domain of the flanker test was in the deficient range at baseline. The presence of urge incontinence affected follow-up results on the sustained attention tests. Treatment with anticholinergic agents did not significantly affect attention variables but changes in several variables were correlated with bladder symptoms and enuresis. Conclusions: Minimal baseline defects in attention function were seen in patients with NME. Follow-up results for some attention variables were affected by daytime symptoms and enuresis. These results suggest that altered brain function in enuretic patients influences improvement in both attention and bladder function.https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-207.pdfcentral nervous systemcholinergic antagonistsnonmonosymptomatic enuresis |
| spellingShingle | Gwan Jang Young Jae Im Jungyo Suh Kwanjin Park Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis Investigative and Clinical Urology central nervous system cholinergic antagonists nonmonosymptomatic enuresis |
| title | Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis |
| title_full | Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis |
| title_fullStr | Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis |
| title_full_unstemmed | Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis |
| title_short | Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis |
| title_sort | changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis |
| topic | central nervous system cholinergic antagonists nonmonosymptomatic enuresis |
| url | https://www.icurology.org/Synapse/Data/PDFData/2020ICU/icu-61-207.pdf |
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