The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration
Anti-vascular endothelial growth factor drugs keep being the main therapy for neovascular age-related macular degeneration (AMD). Possible predictive parameters (demographic, biochemical and/or inflammatory) could anticipate short-term treatment response with ranibizumab. 46 treatment-naive patients...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/1/105 |
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| author | Laura García-Quintanilla Pablo Almuiña-Varela María José Rodríguez-Cid María Gil-Martínez Maximino J. Abraldes Francisco Gómez-Ulla Miguel González-Barcia Cristina Mondelo-García Ana Estany-Gestal Francisco J. Otero-Espinar Maribel Fernández-Rodríguez Anxo Fernández-Ferreiro |
| author_facet | Laura García-Quintanilla Pablo Almuiña-Varela María José Rodríguez-Cid María Gil-Martínez Maximino J. Abraldes Francisco Gómez-Ulla Miguel González-Barcia Cristina Mondelo-García Ana Estany-Gestal Francisco J. Otero-Espinar Maribel Fernández-Rodríguez Anxo Fernández-Ferreiro |
| author_sort | Laura García-Quintanilla |
| collection | DOAJ |
| description | Anti-vascular endothelial growth factor drugs keep being the main therapy for neovascular age-related macular degeneration (AMD). Possible predictive parameters (demographic, biochemical and/or inflammatory) could anticipate short-term treatment response with ranibizumab. 46 treatment-naive patients were included in a prospective observational study. They underwent three monthly injections of intravitreal ranibizumab for neovascular AMD and the clinical examination was made at baseline and one month after the third injection. Demographic characteristics, co-morbidities and concomitant treatments were recorded at the baseline visit. Biochemical parameters, complete blood count and inflammation biomarkers were also measured at these times. Uric Acid was found to be statistically significant with a one-point difference between good and poor responders in both basal and treated patients, but only in basal parameters was statistical significance reached (<i>p</i> = 0.007 vs. <i>p</i> = 0.071 in treated patients). Cholesterol and inflammatory parameters such as white blood cell count and neutrophils were significantly reduced over time when treated with intravitreal ranibizumab. On the other hand, women seemed to have a worse prognosis for short-term response to intravitreal ranibizumab treatment. Uric acid may help identify possible non-responders before initial treatment with ranibizumab, and cholesterol and white blood cells could be good candidates to monitor short-term response to ranibizumab treatment. |
| first_indexed | 2024-03-08T10:37:35Z |
| format | Article |
| id | doaj.art-8a2a71421e404f7386dc9db758f90413 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-08T10:37:35Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8a2a71421e404f7386dc9db758f904132024-01-26T18:07:39ZengMDPI AGPharmaceutics1999-49232024-01-0116110510.3390/pharmaceutics16010105The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular DegenerationLaura García-Quintanilla0Pablo Almuiña-Varela1María José Rodríguez-Cid2María Gil-Martínez3Maximino J. Abraldes4Francisco Gómez-Ulla5Miguel González-Barcia6Cristina Mondelo-García7Ana Estany-Gestal8Francisco J. Otero-Espinar9Maribel Fernández-Rodríguez10Anxo Fernández-Ferreiro11Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainClinical Pharmacology Group, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainOphthalmology Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainOphthalmology Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainOphthalmology Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainInstituto Oftalmológico Gómez-Ulla, 15706 Santiago de Compostela, SpainPharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainPharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainFIDIS-Unidad de Epidemiología e Investigación Clínica, 15706 Santiago de Compostela, SpainPharmacology, Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, SpainOphthalmology Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainPharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706 Santiago de Compostela, SpainAnti-vascular endothelial growth factor drugs keep being the main therapy for neovascular age-related macular degeneration (AMD). Possible predictive parameters (demographic, biochemical and/or inflammatory) could anticipate short-term treatment response with ranibizumab. 46 treatment-naive patients were included in a prospective observational study. They underwent three monthly injections of intravitreal ranibizumab for neovascular AMD and the clinical examination was made at baseline and one month after the third injection. Demographic characteristics, co-morbidities and concomitant treatments were recorded at the baseline visit. Biochemical parameters, complete blood count and inflammation biomarkers were also measured at these times. Uric Acid was found to be statistically significant with a one-point difference between good and poor responders in both basal and treated patients, but only in basal parameters was statistical significance reached (<i>p</i> = 0.007 vs. <i>p</i> = 0.071 in treated patients). Cholesterol and inflammatory parameters such as white blood cell count and neutrophils were significantly reduced over time when treated with intravitreal ranibizumab. On the other hand, women seemed to have a worse prognosis for short-term response to intravitreal ranibizumab treatment. Uric acid may help identify possible non-responders before initial treatment with ranibizumab, and cholesterol and white blood cells could be good candidates to monitor short-term response to ranibizumab treatment.https://www.mdpi.com/1999-4923/16/1/105ranibizumabinflammatorystatinsuric acidage-related macular degeneration |
| spellingShingle | Laura García-Quintanilla Pablo Almuiña-Varela María José Rodríguez-Cid María Gil-Martínez Maximino J. Abraldes Francisco Gómez-Ulla Miguel González-Barcia Cristina Mondelo-García Ana Estany-Gestal Francisco J. Otero-Espinar Maribel Fernández-Rodríguez Anxo Fernández-Ferreiro The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration Pharmaceutics ranibizumab inflammatory statins uric acid age-related macular degeneration |
| title | The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration |
| title_full | The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration |
| title_fullStr | The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration |
| title_full_unstemmed | The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration |
| title_short | The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration |
| title_sort | effect of systemic parameters and baseline characteristics in short term response analysis with intravitreal ranibizumab in treatment naive patients with neovascular age related macular degeneration |
| topic | ranibizumab inflammatory statins uric acid age-related macular degeneration |
| url | https://www.mdpi.com/1999-4923/16/1/105 |
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