Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats
Introduction: Lack of high-quality sleep causes severe side effects like anxiety and changes in plasma concentration of oxalate. The current study investigated the impact of local extremely low-frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats. Methods: In t...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2022-07-01
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| Series: | Basic and Clinical Neuroscience |
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| Online Access: | http://bcn.iums.ac.ir/article-1-1805-en.html |
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| author | Elnaz Azizi Fatemeh Ayoobi Ali Shamsizadeh Amir Moghadam-Ahmadi Seyed Ali Shafiei Alireza Khoshdel Mohammad Reza Mirzaei |
| author_facet | Elnaz Azizi Fatemeh Ayoobi Ali Shamsizadeh Amir Moghadam-Ahmadi Seyed Ali Shafiei Alireza Khoshdel Mohammad Reza Mirzaei |
| author_sort | Elnaz Azizi |
| collection | DOAJ |
| description | Introduction: Lack of high-quality sleep causes severe side effects like anxiety and changes in plasma concentration of oxalate. The current study investigated the impact of local extremely low-frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats.
Methods: In this experimental study, 40 male rats were divided into four groups (n=10 for each group). The ELF-MF exposure (0, 10, and 18 Hz) was applied with an intensity of 200µT for three days (10 min/d). The sham-treated animal did not receive ELF-MF. Serum levels of oxalic acid (OA) and sleepiness were measured before and after the last exposure to ELF-MF or sham. Anxiety, sleepiness, and OA were measured using the elevated plus maze, open-field test (OFT), and ELISA test.
Results: A comparison of oxalate levels before and after exposure to ELF-MF revealed that ELF-MF (10 Hz) decreased the serum level of oxalate (P<0.05). Comparing open/closed arm entry (in an elevated plus maze) between before and after exposure to ELF-MF revealed significant differences. Also, frequency, velocity, and distance moved were decreased in the open-field test.
Conclusion: Results of the present study demonstrated that ELF-MF with short-time exposure may modulate the metabolism of OA and may modulate anxiety-like behavior or kind of induction of sleepiness in male rats. |
| first_indexed | 2024-03-07T18:39:25Z |
| format | Article |
| id | doaj.art-8a2aec94237c4ceb92d85834a32b3c94 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T18:39:25Z |
| publishDate | 2022-07-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-8a2aec94237c4ceb92d85834a32b3c942024-03-02T04:19:55ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422022-07-01134519530Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male RatsElnaz Azizi0Fatemeh Ayoobi1Ali Shamsizadeh2Amir Moghadam-Ahmadi3Seyed Ali Shafiei4Alireza Khoshdel5Mohammad Reza Mirzaei6 Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran. Department of Biochemistry, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Introduction: Lack of high-quality sleep causes severe side effects like anxiety and changes in plasma concentration of oxalate. The current study investigated the impact of local extremely low-frequency magnetic fields (ELF-MFs) on inducing sleep (sleepiness) and anxiety in male rats. Methods: In this experimental study, 40 male rats were divided into four groups (n=10 for each group). The ELF-MF exposure (0, 10, and 18 Hz) was applied with an intensity of 200µT for three days (10 min/d). The sham-treated animal did not receive ELF-MF. Serum levels of oxalic acid (OA) and sleepiness were measured before and after the last exposure to ELF-MF or sham. Anxiety, sleepiness, and OA were measured using the elevated plus maze, open-field test (OFT), and ELISA test. Results: A comparison of oxalate levels before and after exposure to ELF-MF revealed that ELF-MF (10 Hz) decreased the serum level of oxalate (P<0.05). Comparing open/closed arm entry (in an elevated plus maze) between before and after exposure to ELF-MF revealed significant differences. Also, frequency, velocity, and distance moved were decreased in the open-field test. Conclusion: Results of the present study demonstrated that ELF-MF with short-time exposure may modulate the metabolism of OA and may modulate anxiety-like behavior or kind of induction of sleepiness in male rats.http://bcn.iums.ac.ir/article-1-1805-en.htmlmagnetic fieldextremely low-frequency magnetic fields (elf-mfs)oxalic acidanxietysleepiness |
| spellingShingle | Elnaz Azizi Fatemeh Ayoobi Ali Shamsizadeh Amir Moghadam-Ahmadi Seyed Ali Shafiei Alireza Khoshdel Mohammad Reza Mirzaei Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats Basic and Clinical Neuroscience magnetic field extremely low-frequency magnetic fields (elf-mfs) oxalic acid anxiety sleepiness |
| title | Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats |
| title_full | Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats |
| title_fullStr | Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats |
| title_full_unstemmed | Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats |
| title_short | Effect of Short-time Exposure of Local Extremely Low-Frequency Magnetic Fields on Sleepiness in Male Rats |
| title_sort | effect of short time exposure of local extremely low frequency magnetic fields on sleepiness in male rats |
| topic | magnetic field extremely low-frequency magnetic fields (elf-mfs) oxalic acid anxiety sleepiness |
| url | http://bcn.iums.ac.ir/article-1-1805-en.html |
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