Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer
Deubiquitination, a post-translational modification regulated by deubiquitinases, is essential for cancer initiation and progression. Ubiquitin-specific proteases (USPs) are essential elements of the deubiquitinase family, and are overexpressed in gastric cancer (GC). Through the regulation of sever...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222400204X |
| _version_ | 1797248423219429376 |
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| author | Kai-Qiang Li Xiao Bai Ang-Ting Ke Si-Qi Ding Chun-Dong Zhang Dong-Qiu Dai |
| author_facet | Kai-Qiang Li Xiao Bai Ang-Ting Ke Si-Qi Ding Chun-Dong Zhang Dong-Qiu Dai |
| author_sort | Kai-Qiang Li |
| collection | DOAJ |
| description | Deubiquitination, a post-translational modification regulated by deubiquitinases, is essential for cancer initiation and progression. Ubiquitin-specific proteases (USPs) are essential elements of the deubiquitinase family, and are overexpressed in gastric cancer (GC). Through the regulation of several signaling pathways, such as Wnt/β-Catenin and nuclear factor-κB signaling, and the promotion of the expression of deubiquitination- and stabilization-associated proteins, USPs promote the proliferation, metastasis, invasion, and epithelial-mesenchymal transition of GC. In addition, the expression of USPs is closely related to clinicopathological features, patient prognosis, and chemotherapy resistance. USPs therefore could be used as prognostic biomarkers. USP targeting small molecule inhibitors have demonstrated strong anticancer activity. However, they have not yet been tested in the clinic. This article provides an overview of the latest fundamental research on USPs in GC, aiming to enhance the understanding of how USPs contribute to GC progression, and identifying possible targets for GC treatment to improve patient survival. |
| first_indexed | 2024-03-07T22:01:16Z |
| format | Article |
| id | doaj.art-8a2b58db03af40059503a63247d2757c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-24T20:14:21Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-8a2b58db03af40059503a63247d2757c2024-03-23T06:22:44ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-04-01173116323Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancerKai-Qiang Li0Xiao Bai1Ang-Ting Ke2Si-Qi Ding3Chun-Dong Zhang4Dong-Qiu Dai5Department of Surgical Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, ChinaDepartment of Surgical Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, ChinaDepartment of Surgical Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, ChinaDepartment of Surgical Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, ChinaDepartment of Surgical Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, ChinaDepartment of Surgical Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, China; Cancer Center, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, China; Correspondence to: Department of Surgical Oncology and Cancer Center, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province 110032, China.Deubiquitination, a post-translational modification regulated by deubiquitinases, is essential for cancer initiation and progression. Ubiquitin-specific proteases (USPs) are essential elements of the deubiquitinase family, and are overexpressed in gastric cancer (GC). Through the regulation of several signaling pathways, such as Wnt/β-Catenin and nuclear factor-κB signaling, and the promotion of the expression of deubiquitination- and stabilization-associated proteins, USPs promote the proliferation, metastasis, invasion, and epithelial-mesenchymal transition of GC. In addition, the expression of USPs is closely related to clinicopathological features, patient prognosis, and chemotherapy resistance. USPs therefore could be used as prognostic biomarkers. USP targeting small molecule inhibitors have demonstrated strong anticancer activity. However, they have not yet been tested in the clinic. This article provides an overview of the latest fundamental research on USPs in GC, aiming to enhance the understanding of how USPs contribute to GC progression, and identifying possible targets for GC treatment to improve patient survival.http://www.sciencedirect.com/science/article/pii/S075333222400204XGastric cancerUbiquitin-specific proteasesDeubiquitinationInhibitors |
| spellingShingle | Kai-Qiang Li Xiao Bai Ang-Ting Ke Si-Qi Ding Chun-Dong Zhang Dong-Qiu Dai Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer Biomedicine & Pharmacotherapy Gastric cancer Ubiquitin-specific proteases Deubiquitination Inhibitors |
| title | Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer |
| title_full | Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer |
| title_fullStr | Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer |
| title_full_unstemmed | Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer |
| title_short | Ubiquitin-specific proteases: From biological functions to potential therapeutic applications in gastric cancer |
| title_sort | ubiquitin specific proteases from biological functions to potential therapeutic applications in gastric cancer |
| topic | Gastric cancer Ubiquitin-specific proteases Deubiquitination Inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S075333222400204X |
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